In Vitro Analysis of Photosensitizer Accumulation for Assessment of Applicability of Fluorescence Diagnosis of Squamous Cell Carcinoma of Epidermolysis Bullosa Patients
المؤلفون المشاركون
Larisch, Patrick
Verwanger, Thomas
Onder, Kamil
Krammer, Barbara
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-12-30
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Epidermolysis bullosa (EB) is a group of inherited skin disorders characterized by blistering following mechanical trauma.
Chronic wounds of EB patients often lead to tumors such as squamous cell carcinoma (SCC).
Early diagnosis may prevent its invasive growth—frequently the reason of premature mortality of EB-patients.
Early detection of tumors is achieved by fluorescence diagnosis (FD), where photosensitizers localize selectively in tumors and fluoresce upon illumination.
Excessive accumulation of photosensitizers in inflamed areas, as occasionally found at chronic wounds and tumors due to inflammatory processes, leads to false-positive results in FD.
This study analyzed accumulation kinetics of the photosensitizers hypericin and endogenous protoporphyrin IX (PpIX) in different skin cell lines including the three EB subtypes under normal and proinflammatory conditions (stimulated with TNF-alpha).
The aim was to assess the applicability of FD of SCC in EB.
All cell lines accumulate hypericin or PpIX mostly increasing with incubation time, but with different kinetics.
SCC cells of recessive dystrophic EB (RDEB) accumulate less hypericin or PpIX than nonmalignant RDEB cells.
Nevertheless, tumor selectivity in vivo might be existent.
Non-EB cell lines are more active concerning photosensitizer enrichment.
Proinflammatory conditions of skin cell lines seem to have no major influence on photosensitizer accumulation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Larisch, Patrick& Verwanger, Thomas& Onder, Kamil& Krammer, Barbara. 2012. In Vitro Analysis of Photosensitizer Accumulation for Assessment of Applicability of Fluorescence Diagnosis of Squamous Cell Carcinoma of Epidermolysis Bullosa Patients. BioMed Research International،Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-1004504
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Larisch, Patrick…[et al.]. In Vitro Analysis of Photosensitizer Accumulation for Assessment of Applicability of Fluorescence Diagnosis of Squamous Cell Carcinoma of Epidermolysis Bullosa Patients. BioMed Research International No. 2013 (2013), pp.1-14.
https://search.emarefa.net/detail/BIM-1004504
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Larisch, Patrick& Verwanger, Thomas& Onder, Kamil& Krammer, Barbara. In Vitro Analysis of Photosensitizer Accumulation for Assessment of Applicability of Fluorescence Diagnosis of Squamous Cell Carcinoma of Epidermolysis Bullosa Patients. BioMed Research International. 2012. Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-1004504
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1004504
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر