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Milan PM1 Induces Adverse Effects on Mice Lungs and Cardiovascular System
المؤلفون المشاركون
Palestini, Paola
Camatini, Marina
Farina, Francesca
Sancini, Giulio
Longhin, Eleonora
Mantecca, Paride
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-12-27
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Recent studies have suggested a link between inhaled particulate matter (PM) exposure and increased mortality and morbidity associated with cardiorespiratory diseases.
Since the response to PM1 has not yet been deeply investigated, its impact on mice lungs and cardiovascular system is here examined.
A repeated exposure to Milan PM1 was performed on BALB/c mice.
The bronchoalveolar lavage fluid (BALf) and the lung parenchyma were screened for markers of inflammation (cell counts, tumor necrosis factor-α (TNF-α); macrophage inflammatory protein-2 (MIP-2); heme oxygenase-1 (HO-1); nuclear factor kappa-light-chain-enhancer of activated B cells p50 subunit (NFκB-p50); inducible nitric oxide synthetase (iNOS); endothelial-selectin (E-selectin)), cytotoxicity (lactate dehydrogenase (LDH); alkaline phosphatase (ALP); heat shock protein 70 (Hsp70); caspase-8-p18), and a putative pro-carcinogenic marker (cytochrome 1B1 (Cyp1B1)).
Heart tissue was tested for HO-1, caspase-8-p18, NFκB-p50, iNOS, E-selectin, and myeloperoxidase (MPO); plasma was screened for markers of platelet activation and clot formation (soluble platelet-selectin (sP-selectin); fibrinogen; plasminogen activator inhibitor 1 (PAI-1)).
PM1 triggers inflammation and cytotoxicity in lungs.
A similar cytotoxic effect was observed on heart tissues, while plasma analyses suggest blood-endothelium interface activation.
These data highlight the importance of lung inflammation in mediating adverse cardiovascular events following increase in ambient PM1 levels, providing evidences of a positive correlation between PM1 exposure and cardiovascular morbidity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Farina, Francesca& Sancini, Giulio& Longhin, Eleonora& Mantecca, Paride& Camatini, Marina& Palestini, Paola. 2012. Milan PM1 Induces Adverse Effects on Mice Lungs and Cardiovascular System. BioMed Research International،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1004649
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Farina, Francesca…[et al.]. Milan PM1 Induces Adverse Effects on Mice Lungs and Cardiovascular System. BioMed Research International No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1004649
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Farina, Francesca& Sancini, Giulio& Longhin, Eleonora& Mantecca, Paride& Camatini, Marina& Palestini, Paola. Milan PM1 Induces Adverse Effects on Mice Lungs and Cardiovascular System. BioMed Research International. 2012. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1004649
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1004649
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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