A Replication Study from Chinese Supports Association between Lupus-Risk Allele in TNFSF4 and Renal Disorder
المؤلفون المشاركون
Zhou, Xu-jie
Cheng, Fa-juan
Qi, Yuan-yuan
Zhao, Ming-hui
Zhang, Hong
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-07-01
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
A recent phenotypic association study of genetic susceptibility loci in SLE suggested that TNFSF4 gene might be useful to predict renal disorder in lupus patients.
To replicate the association, two single-nucleotide polymorphisms (SNPs: rs2205960 and rs10489265) were genotyped in 814 SLE patients.
Correlations between genotypes and TNFSF4 expression were determined.
The stainings of TNFSF4 in renal biopsy specimens were checked by immunohistochemistry.
The SNPs of TNFSF4 were associated with renal involvement in lupus patients from the Chinese population (P values for rs2205960 and rs10489265 were 0.014 and 0.005 in additive model, resp.).
An association between risk genotypes and low C3 levels was also observed (P=0.034).
Functional prediction suggested that rs2205960 had a regulatory feature.
The risk alleles seemingly correlated with lower TNFSF4 expression.
Strong TNFSF4 expression was detected in lymph nodes and “apparently normal” paratumor renal biopsy but not in renal biopsies from lupus nephritis.
In genome-wide expression data, TNFSF4 was also observed to be downregulated in LN in both glomeruli and tubulointerstitium from kidney biopsies.
However, the associations were marginally significant.
Our data firstly replicated the association of TNFSF4 with renal disorder in SLE patients in the Chinese population, which supported that TNFSF4 may act as a marker of lupus nephritis.
The detailed mechanisms of its role in pathogenesis will still be further needed.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhou, Xu-jie& Cheng, Fa-juan& Qi, Yuan-yuan& Zhao, Ming-hui& Zhang, Hong. 2013. A Replication Study from Chinese Supports Association between Lupus-Risk Allele in TNFSF4 and Renal Disorder. BioMed Research International،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1004692
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhou, Xu-jie…[et al.]. A Replication Study from Chinese Supports Association between Lupus-Risk Allele in TNFSF4 and Renal Disorder. BioMed Research International No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1004692
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhou, Xu-jie& Cheng, Fa-juan& Qi, Yuan-yuan& Zhao, Ming-hui& Zhang, Hong. A Replication Study from Chinese Supports Association between Lupus-Risk Allele in TNFSF4 and Renal Disorder. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1004692
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1004692
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر