Obesity, Insulin Resistance, and Metabolic Syndrome: A Study in WNINOb Rats from a Pancreatic Perspective
المؤلفون المشاركون
Venkatesan, Vijayalakshmi
Madhira, Soundarya L.
Malakapalli, Venkata M.
Chalasani, Maniprabha
Shaik, Sarfaraz N.
Seshadri, Vasudevan
Kodavalla, Venkaiah
Bhonde, Ramesh R.
Nappanveettil, Giridharan
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-19، 19ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-12-15
دولة النشر
مصر
عدد الصفحات
19
التخصصات الرئيسية
الملخص EN
Alterations in pancreatic milieu to adapt to physiological shifts occurring in conditions of obesity and metabolic syndrome (MS) have been documented, though mechanisms leading to such a state have remained elusive so far.
The data presented here tries to look at the gravity of metabolic insult during the early and prolonged phases of obesity/insulin resistance (IR) depicted in WNIN/Ob strain of rats—an obese euglycemic mutant rat model developed indigenously at our institute which is highly vulnerable for a variety of degenerative diseases.
The present results in situ show the participation of several confounding factors in the pancreatic milieu that collectively coprecipitates for a state of profound inflammation in the pancreas (among Mutant compared to Lean/Control) which gets worsened with age.
These include hypertrophy, macrophage infiltration (CD11b/TNFα/IL6), apoptosis, β-cell vacuolation, hyperinsulinemia (HI), and stress markers (RL-77/HSP104/TBARS) all of which correlated well with indices for obesity (2-3 fold), IR (1.5-3 fold), and HI (2-3 fold).
Further, supportive data was also obtained from in vitro studies using islet cell cultures amongst phenotypes.
Taken together, these results advocate that inflammation was the major precipitating factor to cause islet cell dysfunctions (in situ and in vitro) in these Mutant rats compared to their Lean littermates and parental Control.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Venkatesan, Vijayalakshmi& Madhira, Soundarya L.& Malakapalli, Venkata M.& Chalasani, Maniprabha& Shaik, Sarfaraz N.& Seshadri, Vasudevan…[et al.]. 2013. Obesity, Insulin Resistance, and Metabolic Syndrome: A Study in WNINOb Rats from a Pancreatic Perspective. BioMed Research International،Vol. 2013, no. 2013, pp.1-19.
https://search.emarefa.net/detail/BIM-1004729
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Venkatesan, Vijayalakshmi…[et al.]. Obesity, Insulin Resistance, and Metabolic Syndrome: A Study in WNINOb Rats from a Pancreatic Perspective. BioMed Research International No. 2013 (2013), pp.1-19.
https://search.emarefa.net/detail/BIM-1004729
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Venkatesan, Vijayalakshmi& Madhira, Soundarya L.& Malakapalli, Venkata M.& Chalasani, Maniprabha& Shaik, Sarfaraz N.& Seshadri, Vasudevan…[et al.]. Obesity, Insulin Resistance, and Metabolic Syndrome: A Study in WNINOb Rats from a Pancreatic Perspective. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-19.
https://search.emarefa.net/detail/BIM-1004729
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1004729
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر