The Impact of Aspergillus fumigatus Viability and Sensitization to Its Allergens on the Murine Allergic Asthma Phenotype
المؤلفون المشاركون
Pandey, Sumali
Hoselton, Scott A.
Schuh, Jane M.
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-08-26
دولة النشر
مصر
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
Aspergillus fumigatus is a ubiquitously present respiratory pathogen.
The outcome of a pulmonary disease may vary significantly with fungal viability and host immune status.
Our objective in this study was (1) to assess the ability of inhaled irradiation-killed or live A.
fumigatus spores to induce allergic pulmonary disease and (2) to assess the extent to which inhaled dead or live A.
fumigatus spores influence pulmonary symptoms in a previously established allergic state.
Our newly developed fungal delivery apparatus allowed us to recapitulate human exposure through repeated inhalation of dry fungal spores in an animal model.
We found that live A.
fumigatus spore inhalation led to a significantly increased humoral response, pulmonary inflammation, and airway remodeling in naïve mice and is more likely to induce allergic asthma symptoms than the dead spores.
In contrast, in allergic mice, inhalation of dead and live conidia recruited neutrophils and induced goblet cell metaplasia.
This data suggests that asthma symptoms might be exacerbated by the inhalation of live or dead spores in individuals with established allergy to fungal antigens, although the extent of symptoms was less with dead spores.
These results are likely to be important while considering fungal exposure assessment methods and for making informed therapeutic decisions for mold-associated diseases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pandey, Sumali& Hoselton, Scott A.& Schuh, Jane M.. 2013. The Impact of Aspergillus fumigatus Viability and Sensitization to Its Allergens on the Murine Allergic Asthma Phenotype. BioMed Research International،Vol. 2013, no. 2013, pp.1-17.
https://search.emarefa.net/detail/BIM-1004734
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pandey, Sumali…[et al.]. The Impact of Aspergillus fumigatus Viability and Sensitization to Its Allergens on the Murine Allergic Asthma Phenotype. BioMed Research International No. 2013 (2013), pp.1-17.
https://search.emarefa.net/detail/BIM-1004734
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pandey, Sumali& Hoselton, Scott A.& Schuh, Jane M.. The Impact of Aspergillus fumigatus Viability and Sensitization to Its Allergens on the Murine Allergic Asthma Phenotype. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-17.
https://search.emarefa.net/detail/BIM-1004734
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1004734
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر