N-Acetylcysteine Prevents Hypertension via Regulation of the ADMA-DDAH Pathway in Young Spontaneously Hypertensive Rats
المؤلفون المشاركون
Fan, Nai-Chia
Tsai, Chih-Min
Hsu, Chien-Ning
Huang, Li-Tung
Tain, You-Lin
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-12-17
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Asymmetric dimethylarginine (ADMA) reduces nitric oxide (NO), thus causing hypertension.
ADMA is metabolized by dimethylarginine dimethylaminohydrolase (DDAH), which can be inhibited by oxidative stress.
N-Acetylcysteine (NAC), an antioxidant, can facilitate glutathione (GSH) synthesis.
We aimed to determine whether NAC can prevent hypertension by regulating the ADMA-DDAH pathway in spontaneously hypertensive rats (SHR).
Rats aged 4 weeks were assigned into 3 groups (n=8/group): control Wistar Kyoto rats (WKY), SHR, and SHR receiving 2% NAC in drinking water.
All rats were sacrificed at 12 weeks of age.
SHR had higher blood pressure than WKY, whereas NAC-treated animals did not.
SHR had elevated plasma ADMA levels, which was prevented by NAC therapy.
SHR had lower renal DDAH activity than WKY, whereas NAC-treated animals did not.
Renal superoxide production was higher in SHR than in WKY, whereas NAC therapy prevented it.
NAC therapy was also associated with higher GSH-to-oxidized GSH ratio in SHR kidneys.
Moreover, NAC reduced oxidative stress damage in SHR.
The observed antihypertensive effects of NAC in young SHR might be due to restoration of DDAH activity to reduce ADMA, leading to attenuation of oxidative stress.
Our findings highlight the impact of NAC on the development of hypertension by regulating ADMA-DDAH pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fan, Nai-Chia& Tsai, Chih-Min& Hsu, Chien-Ning& Huang, Li-Tung& Tain, You-Lin. 2013. N-Acetylcysteine Prevents Hypertension via Regulation of the ADMA-DDAH Pathway in Young Spontaneously Hypertensive Rats. BioMed Research International،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1004892
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fan, Nai-Chia…[et al.]. N-Acetylcysteine Prevents Hypertension via Regulation of the ADMA-DDAH Pathway in Young Spontaneously Hypertensive Rats. BioMed Research International No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1004892
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fan, Nai-Chia& Tsai, Chih-Min& Hsu, Chien-Ning& Huang, Li-Tung& Tain, You-Lin. N-Acetylcysteine Prevents Hypertension via Regulation of the ADMA-DDAH Pathway in Young Spontaneously Hypertensive Rats. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1004892
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1004892
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر