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Embryotoxic and Teratogenic Effects of Nickel in Swiss Albino Mice during Organogenetic Period
المؤلفون المشاركون
Saini, Shivi
Nair, Neena
Saini, Mali Ram
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-07-15
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The present study evaluates potential hazardous of nickel (Ni+2 as NiCl2·6H2O) to Swiss albino mice fetus.
Ni was administered orally on body weight base from days 6 to 13 of gestation period.
Based on LD50, Ni doses (46.125, 92.25, and 184.5) mg Ni/kg b.wt.
were used.
On day 18 of gestation, uteri of the sacrificed dams were examined.
A dose-dependent decrease (P<0.01) in the body weight of the pregnant females and fetuses during the gestation period was observed.
Number of implant sites and placental weight at all the three dose levels was lower compared with their respective control groups.
Average number of live fetuses/dams reduced significantly (P<0.01) at 184.5 mg Ni/kg b.wt.
with concomitant increase in the percentage of postimplantation death and percentage of resorbed, macerated, and dead fetuses, respectively.
Exposure increased the fetal malformations, namely, hydrocephaly, open eyelids, microphthalmia, exophthalmia, club foot, umbilical hernia, and skeletal anomalies.
Reduced ossification of nasal, frontal, parietal, intraparietal, and supraoccipital bones, absence/gap between the ribs, reduced/fused sternebrae, vertebral centra, and caudal vertebrae, reduced pelvic elements, absence of carpals, metacarpals, tarsals, metatarsals, and phalanges were distinct.
This indicates vulnerability of the mice fetus to nickel during prenatal exposure.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Saini, Shivi& Nair, Neena& Saini, Mali Ram. 2013. Embryotoxic and Teratogenic Effects of Nickel in Swiss Albino Mice during Organogenetic Period. BioMed Research International،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1004907
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Saini, Shivi…[et al.]. Embryotoxic and Teratogenic Effects of Nickel in Swiss Albino Mice during Organogenetic Period. BioMed Research International No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1004907
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Saini, Shivi& Nair, Neena& Saini, Mali Ram. Embryotoxic and Teratogenic Effects of Nickel in Swiss Albino Mice during Organogenetic Period. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1004907
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1004907
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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