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Formulation Development and Stability Studies of Norfloxacin Extended-Release Matrix Tablets
المؤلفون المشاركون
Oliveira, Paulo Renato
Mendes, Cassiana
Klein, Lilian
Sangoi, Maximiliano da Silva
Bernardi, Larissa Sakis
Silva, Marcos Antônio Segatto
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-09-08
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The aim of this research was to develop a new hydrophilic matrix system containing norfloxacin (NFX).
Extended-release tablets are usually intended for once-a-day administration with benefits to the patient and lower discontinuation of the therapy.
Formulations were developed with hydroxypropylmethylcellulose or poly(ethylene oxide) as hydrophilic polymers, with different molecular weights (MWs) and concentrations (20 and 30%).
The tablets were found to be stable (6 months at 40±2°C and 75±5% relative humidity), and the film-coating process is recommended to avoid NFX photodegradation.
The dissolution profiles demonstrated an extended-release of NFX for all developed formulations.
Dissolution curves analyzed using the Korsmeyer exponential equation showed that drug release was controlled by both drug diffusion and polymer relaxation or erosion mechanisms.
A more erosion controlled system was obtained for the formulations containing lower MW and amount of polymer.
With the increase in both MW and amount of polymer in the formulation, the gel layer became stronger, and the dissolution was more drug-diffusion dependent.
Formulations containing intermediate MW polymers or high concentration (30%) of low MW polymers demonstrated a combination of extended and complete in vitro drug release.
This way, these formulations could provide an increased bioavailability in vivo.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Oliveira, Paulo Renato& Mendes, Cassiana& Klein, Lilian& Sangoi, Maximiliano da Silva& Bernardi, Larissa Sakis& Silva, Marcos Antônio Segatto. 2013. Formulation Development and Stability Studies of Norfloxacin Extended-Release Matrix Tablets. BioMed Research International،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1004941
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Oliveira, Paulo Renato…[et al.]. Formulation Development and Stability Studies of Norfloxacin Extended-Release Matrix Tablets. BioMed Research International No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1004941
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Oliveira, Paulo Renato& Mendes, Cassiana& Klein, Lilian& Sangoi, Maximiliano da Silva& Bernardi, Larissa Sakis& Silva, Marcos Antônio Segatto. Formulation Development and Stability Studies of Norfloxacin Extended-Release Matrix Tablets. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1004941
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1004941
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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