Genome Instability at Common Fragile Sites: Searching for the Cause of Their Instability
المؤلف
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-09-05
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Common fragile sites (CFS) are heritable nonrandomly distributed loci on human chromosomes that exhibit an increased frequency of chromosomal breakage under conditions of replication stress.
They are considered the preferential targets for high genomic instability from the earliest stages of human cancer development, and increased chromosome instability at these loci has been observed following replication stress in a subset of human genetic diseases.
Despite their biological and medical relevance, the molecular basis of CFS fragility in vivo has not been fully elucidated.
At present, different models have been proposed to explain how instability at CFS arises and multiple factors seem to contribute to their instability.
However, all these models involve DNA replication and suggest that replication fork stalling along CFS during DNA synthesis is a very frequent event.
Consistent with this, the maintenance of CFS stability relies on the ATR-dependent checkpoint, together with a number of proteins promoting the recovery of stalled replication forks.
In this review, we discuss mainly the possible causes that threaten the integrity of CFS in the light of new findings, paying particular attention to the role of the S-phase checkpoint.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Franchitto, Annapaola. 2013. Genome Instability at Common Fragile Sites: Searching for the Cause of Their Instability. BioMed Research International،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1004979
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Franchitto, Annapaola. Genome Instability at Common Fragile Sites: Searching for the Cause of Their Instability. BioMed Research International No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1004979
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Franchitto, Annapaola. Genome Instability at Common Fragile Sites: Searching for the Cause of Their Instability. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1004979
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1004979
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر