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Immune Responses following Stereotactic Body Radiotherapy for Stage I Primary Lung Cancer
المؤلفون المشاركون
Oguri, Mitsuhiko
Aoki, Shinichi
Kuriyama, Kengo
Maehata, Yoshiyasu
Onishi, Hiroshi
Tominaga, Licht
Araki, Tsutomu
Saito, Ryo
Araya, Masayuki
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-11-10
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Purpose.
Immune responses following stereotactic body radiotherapy (SBRT) for stage I non-small cell lung cancer (NSCLC) were examined from the point of view of lymphocyte subset counts and natural killer cell activity (NKA).
Patients and Methods.
Peripheral blood samples were collected from 62 patients at 4 time points between pretreatment and 4 weeks post-treatment for analysis of the change of total lymphocyte counts (TLC) and lymphocyte subset counts of CD3+, CD4+, CD8+, CD19+, CD56+, and NKA.
In addition, the changes of lymphocyte subset counts were compared between patients with or without relapse.
Further, the correlations between SBRT-related parameters and immune response were analyzed for the purpose of revealing the mechanisms of the immune response.
Results.
All lymphocyte subset counts and NKA at post-treatment and 1 week post-treatment were significantly lower than pre-treatment (P<0.01).
No significant differences in the changes of lymphocyte subset counts were observed among patients with or without relapse.
The volume of the vertebral body receiving radiation doses of 3 Gy or more (VV3) significantly correlated with the changes of nearly all lymphocyte subset counts.
Conclusions.
SBRT for stage I NSCLC induced significant immune suppression, and the decrease of lymphocyte subset counts may be associated with exposure of the vertebral bone marrow.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Maehata, Yoshiyasu& Onishi, Hiroshi& Kuriyama, Kengo& Aoki, Shinichi& Araya, Masayuki& Saito, Ryo…[et al.]. 2013. Immune Responses following Stereotactic Body Radiotherapy for Stage I Primary Lung Cancer. BioMed Research International،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1004982
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Maehata, Yoshiyasu…[et al.]. Immune Responses following Stereotactic Body Radiotherapy for Stage I Primary Lung Cancer. BioMed Research International No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-1004982
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Maehata, Yoshiyasu& Onishi, Hiroshi& Kuriyama, Kengo& Aoki, Shinichi& Araya, Masayuki& Saito, Ryo…[et al.]. Immune Responses following Stereotactic Body Radiotherapy for Stage I Primary Lung Cancer. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1004982
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1004982
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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