Walking on a Tissue-Specific Disease-Protein-Complex Heterogeneous Network for the Discovery of Disease-Related Protein Complexes
المؤلفون المشاركون
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-12-28
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Besides the pinpointing of individual disease-related genes, associating protein complexes to human inherited diseases is also of great importance, because a biological function usually arises from the cooperative behaviour of multiple proteins in a protein complex.
Moreover, knowledge about disease-related protein complexes could also enhance the inference of disease genes and pathogenic genetic variants.
Here, we have designed a computational systems biology approach to systematically analyse potential relationships between diseases and protein complexes.
First, we construct a heterogeneous network which is composed of a disease-disease similarity layer, a tissue-specific protein-protein interaction layer, and a protein complex membership layer.
Then, we propose a random walk model on this disease-protein-complex network for identifying protein complexes that are related to a query disease.
With a series of leave-one-out cross-validation experiments, we show that our method not only possesses high performance but also demonstrates robustness regarding the parameters and the network structure.
We further predict a landscape of associations between human diseases and protein complexes.
This landscape can be used to facilitate the inference of disease genes, thereby benefiting studies on pathology of diseases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jacquemin, Thibault& Jiang, Rui. 2013. Walking on a Tissue-Specific Disease-Protein-Complex Heterogeneous Network for the Discovery of Disease-Related Protein Complexes. BioMed Research International،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1004988
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jacquemin, Thibault& Jiang, Rui. Walking on a Tissue-Specific Disease-Protein-Complex Heterogeneous Network for the Discovery of Disease-Related Protein Complexes. BioMed Research International No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-1004988
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jacquemin, Thibault& Jiang, Rui. Walking on a Tissue-Specific Disease-Protein-Complex Heterogeneous Network for the Discovery of Disease-Related Protein Complexes. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1004988
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1004988
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر