Increased Expression of CCN2 in the Red Flashing Light-Induced Myopia in Guinea Pigs
المؤلفون المشاركون
Wang, Hong
Zhuang, Kang
Gao, Lei
Zhang, Linna
Yang, Hongling
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-07-14
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Visual environment plays an important role in the occurrence of myopia.
We previously showed that the different flashing lights could result in distinct effects on the ocular growth and development of myopia.
CCN2 has been reported to regulate various cellular functions and biological processes.
However, whether CCN2 signaling was involved in the red flashing light-induced myopia still remains unknown.
In the present study, we investigated the effects of the red flashing lights exposure on the refraction and axial length of the eyes in vivo and then evaluated their effects on the expression of CCN2 and TGF-β in sclera tissues.
Our data showed that the eyes exposed to the red flashing light became more myopic with a significant increase of the axial length and decrease of the refraction.
Both CCN2 and TGF-β, as well as p38 MAPK and PI3K, were highly expressed in the sclera tissues exposed to the red flashing light.
Both CCN2 and TGF-β were found to have the same gene expression profile in vivo.
In conclusion, our findings found that CCN2 signaling pathway plays an important role in the red flashing light-induced myopia in vivo.
Moreover, our study establishes a useful animal model for experimental myopia research.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Hong& Zhuang, Kang& Gao, Lei& Zhang, Linna& Yang, Hongling. 2013. Increased Expression of CCN2 in the Red Flashing Light-Induced Myopia in Guinea Pigs. BioMed Research International،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1005071
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Hong…[et al.]. Increased Expression of CCN2 in the Red Flashing Light-Induced Myopia in Guinea Pigs. BioMed Research International No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1005071
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Hong& Zhuang, Kang& Gao, Lei& Zhang, Linna& Yang, Hongling. Increased Expression of CCN2 in the Red Flashing Light-Induced Myopia in Guinea Pigs. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1005071
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1005071
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر