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Two Classifiers Based on Serum Peptide Pattern for Prediction of HBV-Induced Liver Cirrhosis Using MALDI-TOF MS
المؤلفون المشاركون
Cao, Yuan
He, Kun
Cheng, Ming
Si, Hai-Yan
Zhang, He-Lin
Song, Wei
Li, Ai-Ling
Hu, Cheng-Jin
Wang, Na
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-02-19
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Chronic infection with hepatitis B virus (HBV) is associated with the majority of cases of liver cirrhosis (LC) in China.
Although liver biopsy is the reference method for evaluation of cirrhosis, it is an invasive procedure with inherent risk.
The aim of this study is to discover novel noninvasive specific serum biomarkers for the diagnosis of HBV-induced LC.
We performed bead fractionation/MALDI-TOF MS analysis on sera from patients with LC.
Thirteen feature peaks which had optimal discriminatory performance were obtained by using support-vector-machine-(SVM-) based strategy.
Based on the previous results, five supervised machine learning methods were employed to construct classifiers that discriminated proteomic spectra of patients with HBV-induced LC from those of controls.
Here, we describe two novel methods for prediction of HBV-induced LC, termed LC-NB and LC-MLP, respectively.
We obtained a sensitivity of 90.9%, a specificity of 94.9%, and overall accuracy of 93.8% on an independent test set.
Comparisons with the existing methods showed that LC-NB and LC-MLP held better accuracy.
Our study suggests that potential serum biomarkers can be determined for discriminating LC and non-LC cohorts by using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.
These two classifiers could be used for clinical practice in HBV-induced LC assessment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cao, Yuan& He, Kun& Cheng, Ming& Si, Hai-Yan& Zhang, He-Lin& Song, Wei…[et al.]. 2013. Two Classifiers Based on Serum Peptide Pattern for Prediction of HBV-Induced Liver Cirrhosis Using MALDI-TOF MS. BioMed Research International،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1005187
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cao, Yuan…[et al.]. Two Classifiers Based on Serum Peptide Pattern for Prediction of HBV-Induced Liver Cirrhosis Using MALDI-TOF MS. BioMed Research International No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1005187
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cao, Yuan& He, Kun& Cheng, Ming& Si, Hai-Yan& Zhang, He-Lin& Song, Wei…[et al.]. Two Classifiers Based on Serum Peptide Pattern for Prediction of HBV-Induced Liver Cirrhosis Using MALDI-TOF MS. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1005187
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1005187
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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