The Cytotoxic Effect of Magainin II on the MDA-MB-231 and M14K Tumour Cell Lines

المؤلفون المشاركون

Anghel, Radu
Jitaru, Daniela
Bădescu, Magda
Ciocoiu, Manuela
Badescu, Laurentiu

المصدر

BioMed Research International

العدد

المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-11، 11ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2013-10-09

دولة النشر

مصر

عدد الصفحات

11

التخصصات الرئيسية

الطب البشري

الملخص EN

Many studies have highlighted the tumoricidal properties of some natural peptides known to have antimicrobial virtues.

Also, the increasingly higher resistance to conventional antibiotics has become a global public health issue, and the need for new antibiotics has stimulated interest in finding and synthesizing new antimicrobial peptides, which may also be used as chemotherapeutic agents.

Relying on the literature, the purpose of our in vitro research was to assess the tumoricidal potential of magainin II on a series of tumour cell lines, namely, MDA-MB-231 (breast adenocarcinoma) and M14K (human mesothelioma).

The experimental results of our study revealed that the cytotoxic effects of magainin II depend on its concentration.

Its efficiency is significant at 120 μM concentrations, and, although it is much lower, it persists even at 60 μM concentrations.

The effects were insignificant at 30 μM concentrations.

In our experimental research, the tumoricidal effect of magainin II was not significantly dependent on the type of tumour cell line used.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Anghel, Radu& Jitaru, Daniela& Badescu, Laurentiu& Bădescu, Magda& Ciocoiu, Manuela. 2013. The Cytotoxic Effect of Magainin II on the MDA-MB-231 and M14K Tumour Cell Lines. BioMed Research International،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1005216

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Anghel, Radu…[et al.]. The Cytotoxic Effect of Magainin II on the MDA-MB-231 and M14K Tumour Cell Lines. BioMed Research International No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-1005216

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Anghel, Radu& Jitaru, Daniela& Badescu, Laurentiu& Bădescu, Magda& Ciocoiu, Manuela. The Cytotoxic Effect of Magainin II on the MDA-MB-231 and M14K Tumour Cell Lines. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1005216

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1005216