GlutamineGlutamate Metabolism Studied with Magnetic Resonance Spectroscopic Imaging for the Characterization of Adrenal Nodules and Masses
المؤلفون المشاركون
Goldman, Suzan M.
Nunes, Thiago F.
Melo, Homero J. F.
Dalavia, Claudio
Szejnfeld, Denis
Kater, Claudio
Andreoni, Cassio
Szejnfeld, Jacob
Ajzen, Sergio A.
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-10-02
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Purpose.
To assess glutamine/glutamate (Glx) and lactate (Lac) metabolism using proton magnetic resonance spectroscopic imaging (1H-MRS) in order to differentiate between adrenal gland nodules and masses (adenomas, pheochromocytomas, carcinomas, and metastases).
Materials and Methods.
Institutional review board approval and informed consent were obtained.
A total of 130 patients (47 men) with 132 adrenal nodules/masses were prospectively assessed (54±14.8 years).
A multivoxel system was used with a two-dimensional point-resolved spectroscopy/chemical-shift imaging sequence.
Spectroscopic data were interpreted by visual inspection and peak amplitudes of lipids (Lip), choline (Cho), creatine (Cr), Lac, and Glx.
Lac/Cr and Glx/Cr were calculated.
Glx/Cr was assessed in relation to lesion size.
Results.
Statistically significant differences were observed in Glx/Cr results between adenomas and pheochromocytomas (P<0.05), however, with a low positive predictive value (PPV).
Glx levels were directly proportional to lesion size in carcinomas.
A cutoff point of 1.44 was established for the differentiation between carcinomas larger versus smaller than 4 cm, with 75% sensitivity, 100% specificity, 100% PPV, and 80% accuracy.
Lac/Cr results showed no differences across lesions.
A cutoff point of −6.5 for Lac/Cr was established for carcinoma diagnosis.
Conclusion.
Glx levels are directly proportional to lesion size in carcinomas.
A cutoff point of −6.5 Lac/Cr differentiates carcinomas from noncarcinomas.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Goldman, Suzan M.& Nunes, Thiago F.& Melo, Homero J. F.& Dalavia, Claudio& Szejnfeld, Denis& Kater, Claudio…[et al.]. 2013. GlutamineGlutamate Metabolism Studied with Magnetic Resonance Spectroscopic Imaging for the Characterization of Adrenal Nodules and Masses. BioMed Research International،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1005223
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Goldman, Suzan M.…[et al.]. GlutamineGlutamate Metabolism Studied with Magnetic Resonance Spectroscopic Imaging for the Characterization of Adrenal Nodules and Masses. BioMed Research International No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1005223
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Goldman, Suzan M.& Nunes, Thiago F.& Melo, Homero J. F.& Dalavia, Claudio& Szejnfeld, Denis& Kater, Claudio…[et al.]. GlutamineGlutamate Metabolism Studied with Magnetic Resonance Spectroscopic Imaging for the Characterization of Adrenal Nodules and Masses. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1005223
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1005223
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر