Effectiveness of Naltrexone in the Prevention of Delayed Respiratory Arrest in Opioid-Naive Methadone-Intoxicated Patients

المؤلفون المشاركون

Aghabiklooei, Abbas
Hassanian-Moghaddam, Hossein
Zamani, Nasim
Shadnia, Shahin
Mashayekhian, Mohammad
Rahimi, Mitra
Nasouhi, Soheil
Ghoochani, Ahmad

المصدر

BioMed Research International

العدد

المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2013-09-09

دولة النشر

مصر

عدد الصفحات

7

التخصصات الرئيسية

الطب البشري

الملخص EN

Acute methadone toxicity is a major public health concern in Iran.

Methadone-intoxicated patients are in a great risk of recurrent or delayed respiratory arrest despite the prescription of initial doses of naloxone.

This study aimed to evaluate the effectiveness of oral naltrexone in the management of acute methadone overdose in opioid-naive patients and check if it could be a substitute of continuous infusion of naloxone in maintaining adequate ventilation.

In a randomized, double-blind, placebo-controlled study, a total of 54 opioid-naive patients with acute methadone toxicity were enrolled.

The patients received either oral naltrexone or placebo capsules after awakening by naloxone.

All patients underwent close monitoring of respiration.

Frequency of respiratory depression or arrest, need for another dose of naloxone, duration of hospital stay, and adverse outcomes compared between the two groups.

The incidence of respiratory depression was significantly less in those who had received naltrexone.

Our results show that single oral dose of naltrexone is quite efficient in the prevention of recurrent or delayed respiratory arrest in opioid-naive methadone-intoxicated patients.

It can shorten the duration of hospitalization and, as a consequence, decreased the risk of complications.

Further studies are warranted before the generalization of this approach to other patient populations.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Aghabiklooei, Abbas& Hassanian-Moghaddam, Hossein& Zamani, Nasim& Shadnia, Shahin& Mashayekhian, Mohammad& Rahimi, Mitra…[et al.]. 2013. Effectiveness of Naltrexone in the Prevention of Delayed Respiratory Arrest in Opioid-Naive Methadone-Intoxicated Patients. BioMed Research International،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1005363

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Aghabiklooei, Abbas…[et al.]. Effectiveness of Naltrexone in the Prevention of Delayed Respiratory Arrest in Opioid-Naive Methadone-Intoxicated Patients. BioMed Research International No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1005363

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Aghabiklooei, Abbas& Hassanian-Moghaddam, Hossein& Zamani, Nasim& Shadnia, Shahin& Mashayekhian, Mohammad& Rahimi, Mitra…[et al.]. Effectiveness of Naltrexone in the Prevention of Delayed Respiratory Arrest in Opioid-Naive Methadone-Intoxicated Patients. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1005363

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1005363