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The Age-Related Changes in Cartilage and Osteoarthritis
المؤلفون المشاركون
Li, YongPing
Wei, XiaoChun
Zhou, JingMing
Wei, Lei
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-07-21
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Osteoarthritis (OA) is closely associated with aging, but its underlying mechanism is unclear.
Recent publications were reviewed to elucidate the connection between aging and OA.
With increasing OA incidence, more senior people are facing heavy financial and social burdens.
Age-related OA pathogenesis is not well understood.
Recently, it has been realized that age-related changes in other tissues besides articular cartilage may also contribute to OA development.
Many factors including senescence-related secretory phenotypes, chondrocytes’ low reactivity to growth factors, mitochondrial dysfunction and oxidative stress, and abnormal accumulation of advanced glycation end products (AGEs) may all play key roles in the pathogenesis of age-related OA.
Lately, epigenetic regulation of gene expression was recognized for its impact on age-related OA pathogenesis.
Up to now, few studies have been reported about the role of miRNA and long-noncoding RNA (lncRNA) in age-related OA.
Research focusing on this area may provide valuable insights into OA pathogenesis.
OA-induced financial and social burdens have become an increasingly severe threat to older population.
Age-related changes in noncartilage tissue should be incorporated in the understanding of OA development.
Growing attention on oxidative stress and epigenetics will provide more important clues for the better understanding of the age-related OA.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, YongPing& Wei, XiaoChun& Zhou, JingMing& Wei, Lei. 2013. The Age-Related Changes in Cartilage and Osteoarthritis. BioMed Research International،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1005403
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, YongPing…[et al.]. The Age-Related Changes in Cartilage and Osteoarthritis. BioMed Research International No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-1005403
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, YongPing& Wei, XiaoChun& Zhou, JingMing& Wei, Lei. The Age-Related Changes in Cartilage and Osteoarthritis. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1005403
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1005403
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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