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The Cell Surface GRP78 Facilitates the Invasion of Hepatocellular Carcinoma Cells
المؤلفون المشاركون
Zhang, Xiu-Xiu
Li, Hong-Dan
Zhao, Song
Zhao, Liang
Song, Hui-Juan
Wang, Guan
Guo, Qing-Jun
Luan, Zhi-Dong
Su, Rong-Jian
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-12-08
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Invasion is a major characteristic of hepatocellular carcinoma and one of the main causes of refractory to treatment.
We have previously reported that GRP78 promotes the invasion of hepatocellular carcinoma although the mechanism underlying this change remains uncertain.
In this paper, we explored the role of the cell surface GRP78 in the regulation of cancer cell invasion in hepatocellular carcinoma cells.
We found that neutralization of the endogenous cell surface GRP78 with the anti-GRP78 antibody inhibited the adhesion and invasion in hepatocellular carcinoma cell lines Mahlavu and SMMC7721.
However, forced expression of the cell surface GRP78 facilitated the adhesion and invasion in SMMC7721.
We further demonstrated that inhibition of the endogenous cell surface GRP78 specifically inhibited the secretion and activity of MMP-2 but did not affect the secretion and activity of MMP-9.
We also found that inhibition of the cell surface GRP78 increased E-Cadherin expression and decreased N-Cadherin level.
On the contrary, forced expression of the cell surface GRP78 increased N-Cadherin expression and decreased E-Cadherin level, suggesting that the cell surface GRP78 plays critical role in the regulation of EMT process.
These findings suggest that the cell surface GRP78 plays a stimulatory role in the invasion process and may be a potential anti-invasion target for the treatment of hepatocellular carcinoma.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Xiu-Xiu& Li, Hong-Dan& Zhao, Song& Zhao, Liang& Song, Hui-Juan& Wang, Guan…[et al.]. 2013. The Cell Surface GRP78 Facilitates the Invasion of Hepatocellular Carcinoma Cells. BioMed Research International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1005405
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Xiu-Xiu…[et al.]. The Cell Surface GRP78 Facilitates the Invasion of Hepatocellular Carcinoma Cells. BioMed Research International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1005405
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Xiu-Xiu& Li, Hong-Dan& Zhao, Song& Zhao, Liang& Song, Hui-Juan& Wang, Guan…[et al.]. The Cell Surface GRP78 Facilitates the Invasion of Hepatocellular Carcinoma Cells. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1005405
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1005405
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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