Analysis of Complete Genomes of Propionibacterium acnes Reveals a Novel Plasmid and Increased Pseudogenes in an Acne Associated Strain
المؤلفون المشاركون
Kasimatis, Gabriela
Fitz-Gibbon, Sorel
Tomida, Shuta
Wong, Marthew
Li, Huiying
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-05-13
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
The human skin harbors a diverse community of bacteria, including the Gram-positive, anaerobic bacterium Propionibacterium acnes.
P.
acnes has historically been linked to the pathogenesis of acne vulgaris, a common skin disease affecting over 80% of all adolescents in the US.
To gain insight into potential P.
acnes pathogenic mechanisms, we previously sequenced the complete genome of a P.
acnes strain HL096PA1 that is highly associated with acne.
In this study, we compared its genome to the first published complete genome KPA171202.
HL096PA1 harbors a linear plasmid, pIMPLE-HL096PA1.
This is the first described P.
acnes plasmid.
We also observed a five-fold increase of pseudogenes in HL096PA1, several of which encode proteins in carbohydrate transport and metabolism.
In addition, our analysis revealed a few island-like genomic regions that are unique to HL096PA1 and a large genomic inversion spanning the ribosomal operons.
Together, these findings offer a basis for understanding P.
acnes virulent properties, host adaptation mechanisms, and its potential role in acne pathogenesis at the strain level.
Furthermore, the plasmid identified in HL096PA1 may potentially provide a new opportunity for P.
acnes genetic manipulation and targeted therapy against specific disease-associated strains.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kasimatis, Gabriela& Fitz-Gibbon, Sorel& Tomida, Shuta& Wong, Marthew& Li, Huiying. 2013. Analysis of Complete Genomes of Propionibacterium acnes Reveals a Novel Plasmid and Increased Pseudogenes in an Acne Associated Strain. BioMed Research International،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1005408
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kasimatis, Gabriela…[et al.]. Analysis of Complete Genomes of Propionibacterium acnes Reveals a Novel Plasmid and Increased Pseudogenes in an Acne Associated Strain. BioMed Research International No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-1005408
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kasimatis, Gabriela& Fitz-Gibbon, Sorel& Tomida, Shuta& Wong, Marthew& Li, Huiying. Analysis of Complete Genomes of Propionibacterium acnes Reveals a Novel Plasmid and Increased Pseudogenes in an Acne Associated Strain. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1005408
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1005408
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر