![](/images/graphics-bg.png)
The Roles of HyaluronanRHAMMCD44 and Their Respective Interactions along the Insidious Pathways of Fibrosarcoma Progression
المؤلفون المشاركون
Tzanakakis, George N.
Karamanos, Nikos K.
Nikitovic, Dragana
Kouvidi, Katerina
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-09-05
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Fibrosarcomas are rare malignant mesenchymal tumors originating from fibroblasts.
Importantly, fibrosarcoma cells were shown to have a high content and turnover of extracellular matrix (ECM) components including hyaluronan (HA), proteoglycans, collagens, fibronectin, and laminin.
ECMs are complicated structures that surround and support cells within tissues.
During cancer progression, significant changes can be observed in the structural and mechanical properties of the ECM components.
Importantly, hyaluronan deposition is usually higher in malignant tumors as compared to benign tissues, predicting tumor progression in some tumor types.
Furthermore, activated stromal cells are able to produce tissue structure rich in hyaluronan in order to promote tumor growth.
Key biological roles of HA result from its interactions with its specific CD44 and RHAMM (receptor for HA-mediated motility) cell-surface receptors.
HA-receptor downstream signaling pathways regulate in turn cellular processes implicated in tumorigenesis.
Growth factors, including PDGF-BB, TGFβ2, and FGF-2, enhanced hyaluronan deposition to ECM and modulated HA-receptor expression in fibrosarcoma cells.
Indeed, FGF-2 through upregulation of specific HAS isoforms and hyaluronan synthesis regulated secretion and net hyaluronan deposition to the fibrosarcoma pericellular matrix modulating these cells’ migration capability.
In this paper we discuss the involvement of hyaluronan/RHAMM/CD44 mediated signaling in the insidious pathways of fibrosarcoma progression.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nikitovic, Dragana& Kouvidi, Katerina& Karamanos, Nikos K.& Tzanakakis, George N.. 2013. The Roles of HyaluronanRHAMMCD44 and Their Respective Interactions along the Insidious Pathways of Fibrosarcoma Progression. BioMed Research International،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1005445
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nikitovic, Dragana…[et al.]. The Roles of HyaluronanRHAMMCD44 and Their Respective Interactions along the Insidious Pathways of Fibrosarcoma Progression. BioMed Research International No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-1005445
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nikitovic, Dragana& Kouvidi, Katerina& Karamanos, Nikos K.& Tzanakakis, George N.. The Roles of HyaluronanRHAMMCD44 and Their Respective Interactions along the Insidious Pathways of Fibrosarcoma Progression. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1005445
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1005445
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)