Mechanisms of Nanoparticle-Induced Oxidative Stress and Toxicity
المؤلفون المشاركون
Manke, Amruta
Wang, Liying
Rojanasakul, Yon
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-08-20
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
The rapidly emerging field of nanotechnology has offered innovative discoveries in the medical, industrial, and consumer sectors.
The unique physicochemical and electrical properties of engineered nanoparticles (NP) make them highly desirable in a variety of applications.
However, these novel properties of NP are fraught with concerns for environmental and occupational exposure.
Changes in structural and physicochemical properties of NP can lead to changes in biological activities including ROS generation, one of the most frequently reported NP-associated toxicities.
Oxidative stress induced by engineered NP is due to acellular factors such as particle surface, size, composition, and presence of metals, while cellular responses such as mitochondrial respiration, NP-cell interaction, and immune cell activation are responsible for ROS-mediated damage.
NP-induced oxidative stress responses are torch bearers for further pathophysiological effects including genotoxicity, inflammation, and fibrosis as demonstrated by activation of associated cell signaling pathways.
Since oxidative stress is a key determinant of NP-induced injury, it is necessary to characterize the ROS response resulting from NP.
Through physicochemical characterization and understanding of the multiple signaling cascades activated by NP-induced ROS, a systemic toxicity screen with oxidative stress as a predictive model for NP-induced injury can be developed.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Manke, Amruta& Wang, Liying& Rojanasakul, Yon. 2013. Mechanisms of Nanoparticle-Induced Oxidative Stress and Toxicity. BioMed Research International،Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-1005482
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Manke, Amruta…[et al.]. Mechanisms of Nanoparticle-Induced Oxidative Stress and Toxicity. BioMed Research International No. 2013 (2013), pp.1-15.
https://search.emarefa.net/detail/BIM-1005482
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Manke, Amruta& Wang, Liying& Rojanasakul, Yon. Mechanisms of Nanoparticle-Induced Oxidative Stress and Toxicity. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-1005482
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1005482
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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