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Emerging Metabolic Targets in the Therapy of Hematological Malignancies
المؤلفون المشاركون
Leni, Zaira
Parakkal, Geetha
Arcaro, Alexandre
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-08-18
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
During the last decade, the development of anticancer therapies has focused on targeting neoplastic-related metabolism.
Cancer cells display a variety of changes in their metabolism, which enable them to satisfy the high bioenergetic and biosynthetic demands for rapid cell division.
One of the crucial alterations is referred to as the “Warburg effect”, which involves a metabolic shift from oxidative phosphorylation towards the less efficient glycolysis, independent of the presence of oxygen.
Although there are many examples of solid tumors having altered metabolism with high rates of glucose uptake and glycolysis, it was only recently reported that this phenomenon occurs in hematological malignancies.
This review presents evidence that targeting the glycolytic pathway at different levels in hematological malignancies can inhibit cancer cell proliferation by restoring normal metabolic conditions.
However, to achieve cancer regression, high concentrations of glycolytic inhibitors are used due to limited solubility and biodistribution, which may result in toxicity.
Besides using these inhibitors as monotherapies, combinatorial approaches using standard chemotherapeutic agents could display enhanced efficacy at eradicating malignant cells.
The identification of the metabolic enzymes critical for hematological cancer cell proliferation and survival appears to be an interesting new approach for the targeted therapy of hematological malignancies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Leni, Zaira& Parakkal, Geetha& Arcaro, Alexandre. 2013. Emerging Metabolic Targets in the Therapy of Hematological Malignancies. BioMed Research International،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1005488
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Leni, Zaira…[et al.]. Emerging Metabolic Targets in the Therapy of Hematological Malignancies. BioMed Research International No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-1005488
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Leni, Zaira& Parakkal, Geetha& Arcaro, Alexandre. Emerging Metabolic Targets in the Therapy of Hematological Malignancies. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1005488
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1005488
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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