Adaptation or Malignant Transformation: The Two Faces of Epigenetically Mediated Response to Stress
المؤلفون المشاركون
Vojta, Aleksandar
Zoldoš, Vlatka
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-09-26
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Adaptive response to stress is a fundamental property of living systems.
At the cellular level, many different types of stress elicit an essentially limited repertoire of adaptive responses.
Epigenetic changes are the main mechanism for medium- to long-term adaptation to accumulated (intense, long-term, or repeated) stress.
We propose the adaptive deregulation of the epigenome in response to stress (ADERS) hypothesis which assumes that the unspecific adaptive stress response grows stronger with the increasing stress level, epigenetically activating response gene clusters while progressively deregulating other cellular processes.
The balance between the unspecific adaptive response and the general epigenetic deregulation is critical because a strong response can lead to pathology, particularly to malignant transformation.
The main idea of our hypothesis is the continuum traversed by a cell subjected to accumulated stress, which lies between an unspecific adaptive response and pathological deregulation—the two extremes sharing the same underlying cause, which is a manifestation of a unified epigenetically mediated adaptive response to stress.
The evolutionary potential of epigenetic regulation in multigenerational adaptation is speculatively discussed in the light of neo-Lamarckism.
Finally, an approach to testing the proposed hypothesis is presented, relying on either the publicly available datasets or on conducting new experiments.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Vojta, Aleksandar& Zoldoš, Vlatka. 2013. Adaptation or Malignant Transformation: The Two Faces of Epigenetically Mediated Response to Stress. BioMed Research International،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1005505
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Vojta, Aleksandar& Zoldoš, Vlatka. Adaptation or Malignant Transformation: The Two Faces of Epigenetically Mediated Response to Stress. BioMed Research International No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1005505
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Vojta, Aleksandar& Zoldoš, Vlatka. Adaptation or Malignant Transformation: The Two Faces of Epigenetically Mediated Response to Stress. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1005505
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1005505
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر