Maternal Plasma miRNAs Expression in Preeclamptic Pregnancies
المؤلفون المشاركون
Guo, Li
Li, Hailing
Lu, Zuhong
Ge, Qinyu
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-09-09
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Preeclampsia (PE) is a pregnancy-specific syndrome and one of the leading causes of maternal and fetal morbidity and mortality.
The pathophysiological mechanisms of PE remain poorly known.
Recently, circulating miRNAs are considered as potential useful noninvasive biomarkers.
The aim of this study was to identify differentially expressed plasma miRNAs in preeclamptic pregnancies compared with normal pregnancies.
Methods.
Maternal plasma miRNA expression profiles were detected by SOLiD sequencing.
Differential expressions between mPE/sPE and control group were found.
Next, four differentially expressed plasma miRNAs were chosen to validate their expression in other large scale samples by real-time PCR.
Results.
In terms of sequencing results, we identified that 51 miRNAs were differentially expressed.
Four differentially expressed plasma miRNAs (miR-141, miR-144, miR-221, and miR-29a) were selected to validate the sequencing results.
RT-PCR data confirmed the reliability of sequencing results.
The further statistical analysis showed that maternal plasma miR-141 and miR-29a are significantly overexpressed in mPE (P<0.05).
Maternal plasma miR-144 is significantly underexpressed in mPE and sPE (P<0.05).
Conclusions.
Results showed that there were differentially expressed maternal plasma miRNAs in patients with preeclampsia.
These plasma miRNAs might be used as notable biomarkers for diagnosis of preeclampsia.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Hailing& Ge, Qinyu& Guo, Li& Lu, Zuhong. 2013. Maternal Plasma miRNAs Expression in Preeclamptic Pregnancies. BioMed Research International،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1005540
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Hailing…[et al.]. Maternal Plasma miRNAs Expression in Preeclamptic Pregnancies. BioMed Research International No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1005540
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Hailing& Ge, Qinyu& Guo, Li& Lu, Zuhong. Maternal Plasma miRNAs Expression in Preeclamptic Pregnancies. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1005540
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1005540
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر