In Vitro Wound Healing Potential and Identification of Bioactive Compounds from Moringa oleifera Lam
المؤلفون المشاركون
Muhammad, Abubakar Amali
Pauzi, Nur Aimi Syarina
Arulselvan, Palanisamy
Abas, Faridah
Fakurazi, Sharida
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-12-31
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Moringa oleifera Lam.
(M.
oleifera) from the monogeneric family Moringaceae is found in tropical and subtropical countries.
The present study was aimed at exploring the in vitro wound healing potential of M.
oleifera and identification of active compounds that may be responsible for its wound healing action.
The study included cell viability, proliferation, and wound scratch test assays.
Different solvent crude extracts were screened, and the most active crude extract was further subjected to differential bioguided fractionation.
Fractions were also screened and most active aqueous fraction was finally obtained for further investigation.
HPLC and LC-MS/MS analysis were used for identification and confirmation of bioactive compounds.
The results of our study demonstrated that aqueous fraction of M.
oleifera significantly enhanced proliferation and viability as well as migration of human dermal fibroblast (HDF) cells compared to the untreated control and other fractions.
The HPLC and LC-MS/MS studies revealed kaempferol and quercetin compounds in the crude methanolic extract and a major bioactive compound Vicenin-2 was identified in the bioactive aqueous fraction which was confirmed with standard Vicenin-2 using HPLC and UV spectroscopic methods.
These findings suggest that bioactive fraction of M.
oleifera containing Vicenin-2 compound may enhance faster wound healing in vitro.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Muhammad, Abubakar Amali& Pauzi, Nur Aimi Syarina& Arulselvan, Palanisamy& Abas, Faridah& Fakurazi, Sharida. 2013. In Vitro Wound Healing Potential and Identification of Bioactive Compounds from Moringa oleifera Lam. BioMed Research International،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1005552
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Muhammad, Abubakar Amali…[et al.]. In Vitro Wound Healing Potential and Identification of Bioactive Compounds from Moringa oleifera Lam. BioMed Research International No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1005552
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Muhammad, Abubakar Amali& Pauzi, Nur Aimi Syarina& Arulselvan, Palanisamy& Abas, Faridah& Fakurazi, Sharida. In Vitro Wound Healing Potential and Identification of Bioactive Compounds from Moringa oleifera Lam. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1005552
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1005552
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر