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HLA Markers for Poor Prognosis in Systemic Sclerosis Brazilian Patients
المؤلفون المشاركون
Del Rio, Ana Paula Toledo
Sachetto, Zoraida
Sampaio-Barros, Percival Degrava
Marques-Neto, João Francisco
Londe, Ana Carolina Santos
Bertolo, Manoel Barros
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-07-25
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
|Objectives.
The aim of this study was to evaluate human leukocyte antigen (HLA) involvement in the disease expression and poor prognostic clinical features (pulmonary fibrosis and pulmonary arterial hypertension) in patients diagnosed with systemic sclerosis (SSc) in a multiethnic population.
Methods.
SSc patients followed up between 2008 and 2011 were included, and clinical data were obtained through records review.
Molecular HLA typing was performed (polymerase chain reaction amplification technique using specific primer sequences).
The statistical analysis involved Fisher’s exact test and Pearson's corrected chi-square test.
P values≤0.05 were considered significant.
The delta method was used to estimate the variance of the prevalence ratio (PR).
Results.
A total of 141 patients (120 women and 21 men) with SSc were studied, including 33.3% with diffuse cutaneous SSc (dcSSc), 62.4% with limited cutaneous SSc (lcSSc), and 4.3% with sine scleroderma.
Pulmonary fibrosis was present in 61 patients (43.3%), and the HLA-A*30 and DQB1*04 alleles were related to susceptibility.
In contrast, the HLA-DRB1*01 and DQB1*05 alleles were protective.
Pulmonary arterial hypertension was diagnosed in 19 patients (13.5%) and was associated with HLA-B*35 and C*04; in contrast, C*03 seemed to be protective.
Conclusions.
Our current study documents the association of some classes I and II HLA alleles with the most severe clinical manifestations in a multiethnic case series.
Our findings differed slightly from the previous data in other populations.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Del Rio, Ana Paula Toledo& Sachetto, Zoraida& Sampaio-Barros, Percival Degrava& Marques-Neto, João Francisco& Londe, Ana Carolina Santos& Bertolo, Manoel Barros. 2013. HLA Markers for Poor Prognosis in Systemic Sclerosis Brazilian Patients. Disease Markers،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1005811
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Del Rio, Ana Paula Toledo…[et al.]. HLA Markers for Poor Prognosis in Systemic Sclerosis Brazilian Patients. Disease Markers No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1005811
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Del Rio, Ana Paula Toledo& Sachetto, Zoraida& Sampaio-Barros, Percival Degrava& Marques-Neto, João Francisco& Londe, Ana Carolina Santos& Bertolo, Manoel Barros. HLA Markers for Poor Prognosis in Systemic Sclerosis Brazilian Patients. Disease Markers. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1005811
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1005811
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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