![](/images/graphics-bg.png)
Mutation of NPM1 and FLT3 Genes in Acute Myeloid Leukemia and Their Association with Clinical and Immunophenotypic Features
المؤلفون المشاركون
Chauhan, Pradeep Singh
Ihsan, Rakhshan
Singh, L. C.
Gupta, Dipendra Kumar
Mittal, Vishakha
Kapur, Sujala
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-10-29
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Mutations in NPM1 and FLT3 genes represent the most frequent genetic alterations and important diagnostic and prognostic indicators in patients with acute myeloid leukemia (AML).
Objective.
We investigated the prevalence and clinical characteristics of NPM1 and FLT3 mutations in 161 patients of de novo AML including adults and children.
Results.
NPM1 mutation was found in 21% and FLT3 mutation in 25% of the AML patients.
Thirteen (8%) samples were positive for both NPM1 and FLT3/ITD mutations.
Adult patients had significantly higher frequency of NPM1 mutation than children (25.8% versus 8.8%; P=0.02).
Further, NPM1 mutation was found to be more frequent in patients above 45 years of age (P=0.02).
NPM1 mutation was significantly associated with higher platelet count (P=0.05) and absence of hepatosplenomegaly (P=0.01), while FLT3/ITD mutation was associated with higher white blood count (P=0.01).
Immunophenotypically, NPM1 mutation was associated with the lack of CD34 (P<0.001) and HLD-DR expression (P<0.001), while FLT3/ITD mutation was positively associated with the expression of CD7 (P=0.04).
No correlation was found between NPM1 mutation and fusion gene.
Interestingly, FLT3/ITD mutation was found to be inversely associated with AML/ETO fusion gene (P=0.04).
Conclusions.
The results suggest that distinct clinical and immunophenotypic characteristics of NPM1 and FLT3/ITD mutations present further insight into the molecular mechanism of leukemogenesis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chauhan, Pradeep Singh& Ihsan, Rakhshan& Singh, L. C.& Gupta, Dipendra Kumar& Mittal, Vishakha& Kapur, Sujala. 2013. Mutation of NPM1 and FLT3 Genes in Acute Myeloid Leukemia and Their Association with Clinical and Immunophenotypic Features. Disease Markers،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1005846
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chauhan, Pradeep Singh…[et al.]. Mutation of NPM1 and FLT3 Genes in Acute Myeloid Leukemia and Their Association with Clinical and Immunophenotypic Features. Disease Markers No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1005846
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chauhan, Pradeep Singh& Ihsan, Rakhshan& Singh, L. C.& Gupta, Dipendra Kumar& Mittal, Vishakha& Kapur, Sujala. Mutation of NPM1 and FLT3 Genes in Acute Myeloid Leukemia and Their Association with Clinical and Immunophenotypic Features. Disease Markers. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1005846
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1005846
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)