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Acetylcholinesterase Inhibitors Promote Angiogenesis in Chick Chorioallantoic Membrane and Inhibit Apoptosis of Endothelial Cells
المؤلفون المشاركون
Tayarani-Najaran, Zahra
Sadeghnia, Hamid Reza
Mousavi, Seyed Hadi
Parsaee, Heydar
Ghorbani, Ahmad
Mortazavian, Seyed Mohsen
المصدر
International Journal of Alzheimer's Disease
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-09-16
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Alzheimer’s disease (AD) is one of the most common causes of dementia in the elderly.
Recently, a great attention has been paid to the possible role of vascular changes in the pathogenesis of AD.
Reduced microvascular density and degeneration of the endothelium are of structural cerebrovascular changes in AD.
Acetylcholinesterase (AChE) inhibitors are widely used for the improvement of AD symptoms.
Until now, however, the effects of AChE inhibitors on vascular changes including angiogenesis and endothelial cell apoptosis are not fully understood.
In the present work, the effects of three AChE inhibitors (donepezil, rivastigmine, and galantamine) were tested on H2O2-induced apoptosis in human umbilical vein endothelial cells (HUVECs) and on angiogenesis in chicken chorioallantoic membrane model.
Incubation of HUVEC with H2O2 led to a significant decrease in cell viability and an increase in the percentage of apoptotic cells.
The tested drugs, at concentrations of 1–100 μM, significantly inhibited the H2O2-induced toxicity.
Also, all donepezil, rivastigmine and galantamine significantly increased the number of vessels in the chorioallantoic membrane when injected into fertilized eggs.
In conclusion, AChE inhibitors possess angiogenesis-accelerating properties and have antiapoptotic effects on endothelial cells.
These effects of AChE inhibitors may be involved in their beneficial effects on AD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mortazavian, Seyed Mohsen& Parsaee, Heydar& Mousavi, Seyed Hadi& Tayarani-Najaran, Zahra& Ghorbani, Ahmad& Sadeghnia, Hamid Reza. 2013. Acetylcholinesterase Inhibitors Promote Angiogenesis in Chick Chorioallantoic Membrane and Inhibit Apoptosis of Endothelial Cells. International Journal of Alzheimer's Disease،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1005908
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mortazavian, Seyed Mohsen…[et al.]. Acetylcholinesterase Inhibitors Promote Angiogenesis in Chick Chorioallantoic Membrane and Inhibit Apoptosis of Endothelial Cells. International Journal of Alzheimer's Disease No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1005908
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mortazavian, Seyed Mohsen& Parsaee, Heydar& Mousavi, Seyed Hadi& Tayarani-Najaran, Zahra& Ghorbani, Ahmad& Sadeghnia, Hamid Reza. Acetylcholinesterase Inhibitors Promote Angiogenesis in Chick Chorioallantoic Membrane and Inhibit Apoptosis of Endothelial Cells. International Journal of Alzheimer's Disease. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1005908
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1005908
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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