Role of Copper and Cholesterol Association in the Neurodegenerative Process
المؤلفون المشاركون
Marra, Carlos A.
Morel, Gustavo R.
Castillo, Omar
Arnal, Nathalie
de Alaniz, María J. T.
المصدر
International Journal of Alzheimer's Disease
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-10-29
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Age is one of the main factors involved in the development of neurological illnesses, in particular, Alzheimer, and it is widely held that the rapid aging of the world population is accompanied by a rise in the prevalence and incidence of Alzheimer disease.
However, evidence from recent decades indicates that Cu and Cho overload are emerging causative factors in neurodegeneration, a hypothesis that has been partially investigated in experimental models.
The link between these two variables and the onset of Alzheimer disease has opened up interesting new possibilities requiring more in-depth analysis.
The aim of the present study was therefore to investigate the effect of the association of Cu + Cho (CuCho) as a possible synergistic factor in the development of an Alzheimer-like pathology in Wistar rats.
We measured total- and nonceruloplasmin-bound Cu and Cho (free and sterified) contents in plasma and brain zones (cortex and hippocampus), markers of oxidative stress damage, inflammation, and programmed cell death (caspase-3 and calpain isoforms).
The ratio beta-amyloid (1-42)/(1-40) was determined in plasma and brain as neurodegenerative biomarker.
An evaluation of visuospatial memory (Barnes maze test) was also performed.
The results demonstrate the establishment of a prooxidative and proinflammatory environment after CuCho treatment, hallmarked by increased TBARS, protein carbonyls, and nitrite plus nitrate levels in plasma and brain zones (cortex and hippocampus) with a consequent increase in the activity of calpains and no significant changes in caspase-3.
A simultaneous increase in the plasma Aβ1-42/Aβ1-40 ratio was found.
Furthermore, a slight but noticeable change in visuospatial memory was observed in rats treated with CuCho.
We conclude that our model could reflect an initial stage of neurodegeneration in which Cu and Cho interact with one another to exacerbate neurological damage.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Arnal, Nathalie& Morel, Gustavo R.& de Alaniz, María J. T.& Castillo, Omar& Marra, Carlos A.. 2013. Role of Copper and Cholesterol Association in the Neurodegenerative Process. International Journal of Alzheimer's Disease،Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-1005911
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Arnal, Nathalie…[et al.]. Role of Copper and Cholesterol Association in the Neurodegenerative Process. International Journal of Alzheimer's Disease No. 2013 (2013), pp.1-15.
https://search.emarefa.net/detail/BIM-1005911
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Arnal, Nathalie& Morel, Gustavo R.& de Alaniz, María J. T.& Castillo, Omar& Marra, Carlos A.. Role of Copper and Cholesterol Association in the Neurodegenerative Process. International Journal of Alzheimer's Disease. 2013. Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-1005911
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1005911
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر