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Lymphoid Progenitor Cells from Childhood Acute Lymphoblastic Leukemia Are Functionally Deficient and Express High Levels of the Transcriptional Repressor Gfi-1
المؤلفون المشاركون
Mayani, Hector
Hernandez-Rivas, Rosaura
Vadillo, Eduardo
Purizaca, Jessica
Arriaga-Pizano, Lourdes
Pelayo, Rosana
Huerta-Yepez, Sara
Fuentes-Figueroa, Silvestre
Villagomez-Barragán, Horacio
Meza, Isaura
Contreras-Quiroz, Adriana
Dorantes-Acosta, Elisa María
Flores-Guzmán, Patricia
Alvarado-Moreno, Antonio
المصدر
Journal of Immunology Research
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-10-03
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Acute lymphoblastic leukemia (ALL) is the most frequent malignancy of childhood.
Substantial progress on understanding the cell hierarchy within ALL bone marrow (BM) has been recorded in the last few years, suggesting that both primitive cell fractions and committed lymphoid blasts with immature stem cell-like properties contain leukemia-initiating cells.
Nevertheless, the biology of the early progenitors that initiate the lymphoid program remains elusive.
The aim of the present study was to investigate the ability of lymphoid progenitors from B-cell precursor ALL BM to proliferate and undergo multilineage differentiation.
By phenotype analyses, in vitro proliferation assays, and controlled culture systems, the lymphoid differentiation potentials were evaluated in BM primitive populations from B-cell precursor ALL pediatric patients.
When compared to their normal counterparts, functional stem and progenitor cell contents were substantially reduced in ALL BM.
Moreover, neither B nor NK or dendritic lymphoid-cell populations developed recurrently from highly purified ALL-lymphoid progenitors, and their proliferation and cell cycle status revealed limited proliferative capacity.
Interestingly, a number of quiescence-associated transcription factors were elevated, including the transcriptional repressor Gfi-1, which was highly expressed in primitive CD34+ cells.
Together, our findings reveal major functional defects in the primitive hematopoietic component of ALL BM.
A possible contribution of high levels of Gfi-1 expression in the regulation of the stem/progenitor cell biology is suggested.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Purizaca, Jessica& Contreras-Quiroz, Adriana& Dorantes-Acosta, Elisa María& Vadillo, Eduardo& Arriaga-Pizano, Lourdes& Fuentes-Figueroa, Silvestre…[et al.]. 2013. Lymphoid Progenitor Cells from Childhood Acute Lymphoblastic Leukemia Are Functionally Deficient and Express High Levels of the Transcriptional Repressor Gfi-1. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1006643
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Purizaca, Jessica…[et al.]. Lymphoid Progenitor Cells from Childhood Acute Lymphoblastic Leukemia Are Functionally Deficient and Express High Levels of the Transcriptional Repressor Gfi-1. Journal of Immunology Research No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-1006643
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Purizaca, Jessica& Contreras-Quiroz, Adriana& Dorantes-Acosta, Elisa María& Vadillo, Eduardo& Arriaga-Pizano, Lourdes& Fuentes-Figueroa, Silvestre…[et al.]. Lymphoid Progenitor Cells from Childhood Acute Lymphoblastic Leukemia Are Functionally Deficient and Express High Levels of the Transcriptional Repressor Gfi-1. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1006643
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1006643
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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