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Allergenic Characterization of New Mutant Forms of Pru p 3 as New Immunotherapy Vaccines
المؤلفون المشاركون
Garrido-Arandia, M.
Canto, G.
Pacios, L. F.
Díaz-Perales, A.
Tordesillas, L.
Cuesta-Herranz, J.
Gómez-Casado, C.
Varela, J.
Blanca-López, N.
Gamboa, P.
المصدر
Journal of Immunology Research
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-11-14
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Nowadays, treatment of food allergy only considered the avoidance of the specific food.
However, the possibility of cross-reactivity makes this practice not very effective.
Immunotherapy may exhibit as a good alternative to food allergy treatment.
The use of hypoallergenic molecules with reduced IgE binding capacity but with ability to stimulate the immune system is a promising tool which could be developed for immunotherapy.
In this study, three mutants of Pru p 3, the principal allergen of peach, were produced based on the described mimotope and T cell epitopes, by changing the specific residues to alanine, named as Pru p 3.01, Pru p 3.02, and Pru p 3.03.
Pru p 3.01 showed very similar allergenic activity as the wild type by in vitro assays.
However, Pru p 3.02 and Pru p 3.03 presented reduced IgE binding with respect to the native form, by in vitro, ex vivo, and in vivo assays.
In addition, Pru p 3.03 had affected the IgG4 binding capacity and presented a random circular dichroism, which was reflected in the nonrecognition by specific antibodies anti-Pru p 3.
Nevertheless, both Pru p 3.02 and Pru p 3.03 maintained the binding to IgG1 and their ability to activate T lymphocytes.
Thus, Pru p 3.02 and Pru p 3.03 could be good candidates for potential immunotherapy in peach-allergic patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gómez-Casado, C.& Garrido-Arandia, M.& Gamboa, P.& Blanca-López, N.& Canto, G.& Varela, J.…[et al.]. 2013. Allergenic Characterization of New Mutant Forms of Pru p 3 as New Immunotherapy Vaccines. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1006669
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gómez-Casado, C.…[et al.]. Allergenic Characterization of New Mutant Forms of Pru p 3 as New Immunotherapy Vaccines. Journal of Immunology Research No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-1006669
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gómez-Casado, C.& Garrido-Arandia, M.& Gamboa, P.& Blanca-López, N.& Canto, G.& Varela, J.…[et al.]. Allergenic Characterization of New Mutant Forms of Pru p 3 as New Immunotherapy Vaccines. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1006669
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1006669
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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