Clinical Differences between Men and Women with Psoriatic Arthritis: Relevance of the Analysis of Genes and Polymorphisms in the Major Histocompatibility Complex Region and of the Age at Onset of Psoriasis
المؤلفون المشاركون
Alonso, Sara
Ballina, Javier
Sarasqueta, Cristina
López-Larrea, Carlos
Martínez-Borra, Jesús
Coto-Segura, Pablo
González, Segundo
Tejón, Patricia
Alperi, Mercedes
Queiro, Rubén
المصدر
Journal of Immunology Research
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-04-16
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
It has been shown that males with spondyloarthritis tend to suffer from more severe spinal disease while females are more likely to have peripheral joint involvement.
Nevertheless, gender-related differences have not been thoroughly explored in psoriatic arthritis (PsA).
In PsA, males accumulate more peripheral and axial joint damage compared to women.
However, it is not clear whether these findings are secondary to differences in occupational physical activity, hormonal changes, or other factors.
The present study analyzed the differences in clinical expression of PsA between men and women.
We have also evaluated the possible existence of gender-linked differences in the distribution of genes and polymorphisms within the major histocompatibility complex and whether patients’ age at the onset of psoriasis established any differences in these aspects.
Women suffered more polyarthritis, greater functional impairment, and a larger number of swollen joints during followup.
We appreciated a differential expression of certain MHC genes according to gender and age at onset of psoriasis.
Our results point to the need to include patient’s age at the onset of psoriasis and gender as key stratification elements in future studies of genetic associations in PsA.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Queiro, Rubén& Tejón, Patricia& Coto-Segura, Pablo& Alonso, Sara& Alperi, Mercedes& Sarasqueta, Cristina…[et al.]. 2013. Clinical Differences between Men and Women with Psoriatic Arthritis: Relevance of the Analysis of Genes and Polymorphisms in the Major Histocompatibility Complex Region and of the Age at Onset of Psoriasis. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1006770
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Queiro, Rubén…[et al.]. Clinical Differences between Men and Women with Psoriatic Arthritis: Relevance of the Analysis of Genes and Polymorphisms in the Major Histocompatibility Complex Region and of the Age at Onset of Psoriasis. Journal of Immunology Research No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1006770
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Queiro, Rubén& Tejón, Patricia& Coto-Segura, Pablo& Alonso, Sara& Alperi, Mercedes& Sarasqueta, Cristina…[et al.]. Clinical Differences between Men and Women with Psoriatic Arthritis: Relevance of the Analysis of Genes and Polymorphisms in the Major Histocompatibility Complex Region and of the Age at Onset of Psoriasis. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1006770
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1006770
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر