Conversion to Sirolimus Therapy in Kidney Transplant Recipients with New Onset Diabetes Mellitus after Transplantation
المؤلفون المشاركون
Veroux, Pierfrancesco
Veroux, Massimiliano
Guerrieri, Carmela
Sinagra, Nunziata
Zerbo, Domenico
Tallarita, Tiziano
Cimino, Sebastiano
Corona, Daniela
D'Assoro, Antonino
Giaquinta, Alessia
المصدر
Journal of Immunology Research
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-05-20
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
New-onset diabetes mellitus after transplantation (NODAT) may complicate 2–50% of kidney transplantation, and it is associated with reduced graft and patient survivals.
In this retrospective study, we applied a conversion protocol to sirolimus in a cohort of kidney transplant recipients with NODAT.
Among 344 kidney transplant recipients, 29 patients developed a NODAT (6.6%) and continued with a reduced dose of calcineurin inhibitors (CNI) (8 patients, Group A) or were converted to sirolimus (SIR) (21 patients, Group B).
NODAT resolved in 37.5% and in 80% patients in Group A and Group B, respectively.
In Group A, patient and graft survivals were 100% and 75%, respectively, not significantly different from Group B (83.4% and 68%, resp., P=0.847).
Graft function improved after conversion to sirolimus therapy: serum creatinine was 1.8 ± 0.7 mg/dL at the time of conversion and 1.6 ± 0.4 mg/dL five years after conversion to sirolimus therapy (P<0.05), while in the group of patients remaining with a reduced dose of CNI, serum creatinine was 1.7 ± 0.6 mg/dL at the time of conversion and 1.65 ± 0.6 mg/dL at five-year followup (P=0.732).
This study demonstrated that the conversion from CNI to SIR in patients could improve significantly the metabolic parameters of patients with NODAT, without increasing the risk of acute graft rejection.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Veroux, Massimiliano& Tallarita, Tiziano& Corona, Daniela& Sinagra, Nunziata& Giaquinta, Alessia& Zerbo, Domenico…[et al.]. 2013. Conversion to Sirolimus Therapy in Kidney Transplant Recipients with New Onset Diabetes Mellitus after Transplantation. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1006776
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Veroux, Massimiliano…[et al.]. Conversion to Sirolimus Therapy in Kidney Transplant Recipients with New Onset Diabetes Mellitus after Transplantation. Journal of Immunology Research No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1006776
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Veroux, Massimiliano& Tallarita, Tiziano& Corona, Daniela& Sinagra, Nunziata& Giaquinta, Alessia& Zerbo, Domenico…[et al.]. Conversion to Sirolimus Therapy in Kidney Transplant Recipients with New Onset Diabetes Mellitus after Transplantation. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1006776
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1006776
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر