Modification of Intestinal Microbiota and Its Consequences for Innate Immune Response in the Pathogenesis of Campylobacteriosis
المؤلفون المشاركون
Tareen, Abdul Malik
Masanta, Wycliffe Omurwa
Bereswill, Stefan
Zautner, Andreas E.
Heimesaat, Markus M.
Groß, Uwe
Lugert, Raimond
المصدر
Journal of Immunology Research
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-11-14
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Campylobacter jejuni is the leading cause of bacterial food-borne gastroenteritis in the world, and thus one of the most important public health concerns.
The initial stage in its pathogenesis after ingestion is to overcome colonization resistance that is maintained by the human intestinal microbiota.
But how it overcomes colonization resistance is unknown.
Recently developed humanized gnotobiotic mouse models have provided deeper insights into this initial stage and host’s immune response.
These studies have found that a fat-rich diet modifies the composition of the conventional intestinal microbiota by increasing the Firmicutes and Proteobacteria loads while reducing the Actinobacteria and Bacteroidetes loads creating an imbalance that exposes the intestinal epithelial cells to adherence.
Upon adherence, deoxycholic acid stimulates C.
jejuni to synthesize Campylobacter invasion antigens, which invade the epithelial cells.
In response, NF-κB triggers the maturation of dendritic cells.
Chemokines produced by the activated dendritic cells initiate the clearance of C.
jejuni cells by inducing the actions of neutrophils, B-lymphocytes, and various subsets of T-cells.
This immune response causes inflammation.
This review focuses on the progress that has been made on understanding the relationship between intestinal microbiota shift, establishment of C.
jejuni infection, and consequent immune response.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Masanta, Wycliffe Omurwa& Heimesaat, Markus M.& Bereswill, Stefan& Tareen, Abdul Malik& Lugert, Raimond& Groß, Uwe…[et al.]. 2013. Modification of Intestinal Microbiota and Its Consequences for Innate Immune Response in the Pathogenesis of Campylobacteriosis. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1006788
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Masanta, Wycliffe Omurwa…[et al.]. Modification of Intestinal Microbiota and Its Consequences for Innate Immune Response in the Pathogenesis of Campylobacteriosis. Journal of Immunology Research No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1006788
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Masanta, Wycliffe Omurwa& Heimesaat, Markus M.& Bereswill, Stefan& Tareen, Abdul Malik& Lugert, Raimond& Groß, Uwe…[et al.]. Modification of Intestinal Microbiota and Its Consequences for Innate Immune Response in the Pathogenesis of Campylobacteriosis. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1006788
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1006788
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر