The Role of Cytokines in the Functional Activity of Phagocytes in Blood and Colostrum of Diabetic Mothers

المؤلفون المشاركون

Morceli, Glilciane
Fagundes, Danny Laura Gomes
França, Eduardo Luzía
Calderon, Iracema de Mattos Paranhos
Rudge, Marilza Vieira Cunha
Honorio-França, Adenilda Cristina

المصدر

Journal of Immunology Research

العدد

المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2013-12-17

دولة النشر

مصر

عدد الصفحات

8

التخصصات الرئيسية

الأحياء

الملخص EN

Immune response changes induced by diabetes are a risk factor for infections during pregnancy and may modify the development of the newborn’s immune system.

The present study analyzed colostrum and maternal and cord blood of diabetic women to determine (1) the levels of the cytokines IFN-γ and TGF-β and (2) phagocytic activity after incubation with cytokines.

Methods.

Colostrum and maternal and cord blood samples were classified into normoglycemic (N = 20) and diabetic (N = 19) groups.

Cytokine levels, superoxide release, rate of phagocytosis, bactericidal activity, and intracellular Ca2+ release by phagocytes were analyzed in the samples.

Irrespective of glycemic status, IFN-γ and TGF-β levels were not changed in colostrum and maternal and cord blood.

In maternal blood and colostrum, superoxide release by cytokine-stimulated phagocytes was similar between the groups.

Compared to spontaneous release, superoxide release was stimulated by IFN-γ and TGF-β in normoglycemic and diabetic groups.

In the diabetic group, cord blood phagocytes incubated with IFN-γ exhibited higher phagocytic activity in response to EPEC, and maternal blood exhibited lower microbicidal activity.

These data suggest that diabetes interferes in maternal immunological parameters and that IFN-γ and TGF-β modulate the functional activity of phagocytes in the colostrum, maternal blood, and cord blood of pregnant diabetic women.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Fagundes, Danny Laura Gomes& França, Eduardo Luzía& Morceli, Glilciane& Rudge, Marilza Vieira Cunha& Calderon, Iracema de Mattos Paranhos& Honorio-França, Adenilda Cristina. 2013. The Role of Cytokines in the Functional Activity of Phagocytes in Blood and Colostrum of Diabetic Mothers. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1006811

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Fagundes, Danny Laura Gomes…[et al.]. The Role of Cytokines in the Functional Activity of Phagocytes in Blood and Colostrum of Diabetic Mothers. Journal of Immunology Research No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1006811

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Fagundes, Danny Laura Gomes& França, Eduardo Luzía& Morceli, Glilciane& Rudge, Marilza Vieira Cunha& Calderon, Iracema de Mattos Paranhos& Honorio-França, Adenilda Cristina. The Role of Cytokines in the Functional Activity of Phagocytes in Blood and Colostrum of Diabetic Mothers. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1006811

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1006811