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Understanding Dendritic Cells and Their Role in Cutaneous Carcinoma and Cancer Immunotherapy
المؤلفون المشاركون
Mitsui, Hiroshi
Carucci, John A.
Felsen, Diane
Yanofsky, Valerie R.
المصدر
Journal of Immunology Research
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-03-28
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Dendritic cells (DC) represent a diverse group of professional antigen-presenting cells that serve to link the innate and adaptive immune systems.
Their capacity to initiate a robust and antigen-specific immune response has made them the ideal candidates for cancer immunotherapies.
To date, the clinical impact of DC immunotherapy has been limited, which may, in part, be explained by the complex nature of DC biology.
Multiple distinct subsets of DCs have been identified in the skin, where they can be broadly subcategorized into epidermal Langerhans cells (LC), myeloid-derived dermal dendritic cells (mDC) and plasmacytoid dendritic cells (pDC).
Each subset is functionally unique and may activate alternate branches of the immune system.
This may be relevant for the treatment of squamous cell carcinoma, where we have shown that the tumor microenvironment may preferentially suppress the activity of mDCs, while LCs remain potent stimulators of immunity.
Here, we provide an in depth analysis of DC biology, with a particular focus on skin DCs and their role in cutaneous carcinoma.
We further explore the current approaches to DC immunotherapy and provide evidence for the targeting of LCs as a promising new strategy in the treatment of skin cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yanofsky, Valerie R.& Mitsui, Hiroshi& Felsen, Diane& Carucci, John A.. 2013. Understanding Dendritic Cells and Their Role in Cutaneous Carcinoma and Cancer Immunotherapy. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-1006830
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yanofsky, Valerie R.…[et al.]. Understanding Dendritic Cells and Their Role in Cutaneous Carcinoma and Cancer Immunotherapy. Journal of Immunology Research No. 2013 (2013), pp.1-14.
https://search.emarefa.net/detail/BIM-1006830
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yanofsky, Valerie R.& Mitsui, Hiroshi& Felsen, Diane& Carucci, John A.. Understanding Dendritic Cells and Their Role in Cutaneous Carcinoma and Cancer Immunotherapy. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-1006830
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1006830
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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