Increased Frequency of Bone Marrow T Follicular Helper Cells in Patients with Immune-Related Pancytopenia

المؤلفون المشاركون

Shao, Zonghong
Ding, Kai
Liu, Hui
Wang, Huaquan
Li, Lijuan
Wang, Honglei
Yu, Hong
Wang, Yihao
Zhang, Jiangbo
Fu, Rong

المصدر

Journal of Immunology Research

العدد

المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-10، 10ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2013-08-27

دولة النشر

مصر

عدد الصفحات

10

التخصصات الرئيسية

الأحياء

الملخص EN

Immune-related pancytopenia (IRP) is one kind of bone marrow failure diseases which is related to autoantibodies.

Autoantibodies have been detected on the membrane of various bone marrow (BM) hemopoietic cells by BM mononuclear-cell-Coombs test or flow cytometric analysis.

There are autoantibodies in the BM supernatant of IRP patients, which can target several antigens on hematopoietic cells membranes by western blot.

T follicular helper (Tfh) cells are the true helper cells for Ab responses, which represent one of the most numerous and important subsets of effector T cells.

Dysregulation of Tfh cell function or expression of Tfh cell-associated molecules could contribute to the pathogenesis of autoimmune diseases.

Currently, there are no studies regarding the role of Tfh cells in IRP patients.

The percentages of Tfh cells, Tfh-related molecules ICOS, CD40L, IL-21, and Bcl-6 in BM were investigated in 90 patients with IRP, and 25 healthy controls.

We observed that there exist increased quantity and hyperfunction of Tfh cells in IRP, and the results were correlated with patient characteristics.

It was indicated that dysregulated Tfh cells might be involved in the pathogenesis of IRP and that inhibition of Tfh cells effector molecules might provide opportunities for new therapeutic approaches to IRP and even other human autoimmune diseases.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Yu, Hong& Zhang, Jiangbo& Fu, Rong& Liu, Hui& Wang, Huaquan& Ding, Kai…[et al.]. 2013. Increased Frequency of Bone Marrow T Follicular Helper Cells in Patients with Immune-Related Pancytopenia. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1006905

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Yu, Hong…[et al.]. Increased Frequency of Bone Marrow T Follicular Helper Cells in Patients with Immune-Related Pancytopenia. Journal of Immunology Research No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1006905

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Yu, Hong& Zhang, Jiangbo& Fu, Rong& Liu, Hui& Wang, Huaquan& Ding, Kai…[et al.]. Increased Frequency of Bone Marrow T Follicular Helper Cells in Patients with Immune-Related Pancytopenia. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1006905

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1006905