New Insights on Human Polyomavirus JC and Pathogenesis of Progressive Multifocal Leukoencephalopathy

المؤلفون المشاركون

Bellizzi, Anna
Pietropaolo, Valeria
Rodio, Donatella Maria
Nencioni, Lucia
Palamara, Anna Teresa
Anzivino, Elena

المصدر

Journal of Immunology Research

العدد

المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-17، 17ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2013-04-16

دولة النشر

مصر

عدد الصفحات

17

التخصصات الرئيسية

الأحياء

الملخص EN

John Cunningham virus (JCV) is a member of the Polyomaviridae family.

It was first isolated from the brain of a patient with Hodgkin disease in 1971, and since then the etiological agent of the progressive multifocal leukoencephalopathy (PML) was considered.

Until the human immunodeficiency virus (HIV) pandemic, PML was rare: in fact HIV-induced immunodeficiency is the most common predisposing factor accounting for 85% of all instances of PML.

This data led to intense research on JCV infection and resulted in better understanding of epidemiology and clinic-pathologic spectrum.

Recently, cases of PML have been observed after the introduction of monoclonal antibodies, such as natalizumab, rituximab, efalizumab, and infliximab, in the treatment of autoimmune disease, underlining the important role of host immunity in PML pathogenesis.

In this review current understanding of the JCV infection and the new findings relating to the pathogenesis of PML has been comprehensively revised, focusing our attention on the interaction between the cellular and viral molecular pathways implicated in the JCV infection and the modulating role of host immune surveillance in the viral reactivation from a latent state.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Bellizzi, Anna& Anzivino, Elena& Rodio, Donatella Maria& Palamara, Anna Teresa& Nencioni, Lucia& Pietropaolo, Valeria. 2013. New Insights on Human Polyomavirus JC and Pathogenesis of Progressive Multifocal Leukoencephalopathy. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-17.
https://search.emarefa.net/detail/BIM-1006951

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Bellizzi, Anna…[et al.]. New Insights on Human Polyomavirus JC and Pathogenesis of Progressive Multifocal Leukoencephalopathy. Journal of Immunology Research No. 2013 (2013), pp.1-17.
https://search.emarefa.net/detail/BIM-1006951

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Bellizzi, Anna& Anzivino, Elena& Rodio, Donatella Maria& Palamara, Anna Teresa& Nencioni, Lucia& Pietropaolo, Valeria. New Insights on Human Polyomavirus JC and Pathogenesis of Progressive Multifocal Leukoencephalopathy. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-17.
https://search.emarefa.net/detail/BIM-1006951

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1006951