Aberrant T Helper 17 Cells and Related Cytokines in Bone Marrow Microenvironment of Patients with Acute Myeloid Leukemia
المؤلفون المشاركون
Zhang, Hua
Ji, Chunyan
Yuan, Cunzhong
Yu, Shuang
Wang, Min
Tian, Tian
Ma, Daoxin
المصدر
Journal of Immunology Research
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-08-18
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
In this study, we mainly investigate the role of Th17 cells, Th1 cells, and their related cytokines in the pathophysiology of AML.
BM and PB were extracted from ND, CR, and relapsed-refractory AML patients and controls.
Th subsets frequencies were examined by flow cytometry.
BM plasma Th-associated cytokines levels were determined by ELISA.
The frequencies of Th17 and Th1, and IFN-γ or TGF-β concentrations were significantly decreased in ND compared with CR patients or controls.
Th17 percentage was significantly lower in BM than in PB for ND patients but was higher in BM for CR patients.
However, in CR or relapsed-refractory patients, Th1 percentage in BM was higher than that in PB.
Moreover, BM IL-17A level showed a decreased trend in ND patients.
A significant elevation of plasma IL-6 level was found in ND compared with CR patients or controls.
IL-17A showed the positive correlation with IL-6 concentration.
And Th17 cells frequencies and TGF-β1 concentration were increased in BM from AML patients achieving CR after chemotherapy.
Moreover, a significant decrease of BM plasma TGF-β1 level was found in M3 patients compared with the other subtypes.
Our findings suggest that Th17 and related cytokines may be implicated in AML pathogenesis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tian, Tian& Yu, Shuang& Wang, Min& Yuan, Cunzhong& Zhang, Hua& Ji, Chunyan…[et al.]. 2013. Aberrant T Helper 17 Cells and Related Cytokines in Bone Marrow Microenvironment of Patients with Acute Myeloid Leukemia. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1007000
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tian, Tian…[et al.]. Aberrant T Helper 17 Cells and Related Cytokines in Bone Marrow Microenvironment of Patients with Acute Myeloid Leukemia. Journal of Immunology Research No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1007000
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tian, Tian& Yu, Shuang& Wang, Min& Yuan, Cunzhong& Zhang, Hua& Ji, Chunyan…[et al.]. Aberrant T Helper 17 Cells and Related Cytokines in Bone Marrow Microenvironment of Patients with Acute Myeloid Leukemia. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1007000
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1007000
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر