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Significance of Semiquantitative Assessment of Preformed Donor-Specific Antibody Using Luminex Single Bead Assay in Living Related Liver Transplantation
المؤلفون المشاركون
Miyagawa-Hayashino, Aya
Hishida, Rie
Ashihara, Eishi
Uemoto, Sinji
Yoshizawa, Atsushi
Tsuji, Hiroaki
Egawa, Hiroto
Maekawa, Taira
Yurugi, Kimiko
Teramukai, Satoshi
Haga, Hironori
المصدر
Journal of Immunology Research
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-05-29
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Aim.
To analyze the risks of preoperatively produced donor-specific antibody (DSA) in liver transplantation.
Methods.
DSA was assessed using direct complement-dependent cytotoxicity (CDC) and anti-human globulin- (AHG-) CDC tests, as well as the Luminex Single Antigen assay.
Among 616 patients undergoing blood type identical or compatible living donor liver transplantation (LDLT), 21 patients were positive for CDC or AHG-CDC tests, and the preserved serum from 18 patients was examined to determine targeted Class I and II antigens.
The relationships between the mean fluorescence intensity (MFI) of DSA and the clinical outcomes were analyzed.
Results.
Patients were divided into 3 groups according to the MFI of anti-Class I DSA: high (11 patients with MFI > 10,000), low (2 patients with MFI < 10,000), and negative (5 patients) MFI groups.
Six of 11 patients with high Class-I DSA showed positive Class-II DSA.
Hospital death occurred in 7 patients of the high MFI group.
High MFI was a significant risk factor for mortality (P=0.0155).
Univariate analysis showed a significant correlation between MFI strength and C4d deposition (P=0.0498).
Conclusions.
HLA Class I DSA with MFI > 10,000 had a significant negative effect on the clinical outcome of patients with preformed DSA in LDLT.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yoshizawa, Atsushi& Egawa, Hiroto& Yurugi, Kimiko& Hishida, Rie& Tsuji, Hiroaki& Ashihara, Eishi…[et al.]. 2013. Significance of Semiquantitative Assessment of Preformed Donor-Specific Antibody Using Luminex Single Bead Assay in Living Related Liver Transplantation. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1007028
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yoshizawa, Atsushi…[et al.]. Significance of Semiquantitative Assessment of Preformed Donor-Specific Antibody Using Luminex Single Bead Assay in Living Related Liver Transplantation. Journal of Immunology Research No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1007028
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yoshizawa, Atsushi& Egawa, Hiroto& Yurugi, Kimiko& Hishida, Rie& Tsuji, Hiroaki& Ashihara, Eishi…[et al.]. Significance of Semiquantitative Assessment of Preformed Donor-Specific Antibody Using Luminex Single Bead Assay in Living Related Liver Transplantation. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1007028
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1007028
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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