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Acute Oral Toxicity and Kinetic Behaviors of Inorganic Layered Nanoparticles
المؤلفون المشاركون
Choi, Soo-Jin
Yu, Jin
Chung, Hea-Eun
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-10-23
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Layered double hydroxide (LDH) nanoparticles, also known as anionic clays, have attracted a great deal of interest for their potential as delivery carriers.
Recent studies showed that LDH nanoparticles can efficiently deliver drugs or bioactive molecules into cells, which are highly related to their endocytic pathway.
However, the efficient cell permeation capacity of LDH may also raise concern about their toxicity potential.
In this study, the acute oral toxicity of LDH nanoparticles was assessed, and their kinetic behaviors, such as plasma concentration-time curve, tissue distribution, and excretion, were also evaluated in mice.
No significant effects of oral LDH nanoparticles on behaviors, body weight gain, survival rate, and organosomatic index were observed up to the dose of 2000 mg/kg for 14 days.
Serum biochemical parameters did not significantly increase, indicating that LDH nanoparticles did not cause acute liver or kidney injury.
Plasma concentration of LDH nanoparticles rapidly decreased within 30 min depending on exposure doses, but they did not accumulate in any specific organ.
Their excretion via urine and feces was observed within 24 h.
These findings suggest that LDH nanoparticles do not exhibit acute oral toxicity and favorable kinetic behaviors in mice and, therefore, will be promising candidates for biological and pharmaceutical applications.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yu, Jin& Chung, Hea-Eun& Choi, Soo-Jin. 2013. Acute Oral Toxicity and Kinetic Behaviors of Inorganic Layered Nanoparticles. Journal of Nanomaterials،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1008006
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yu, Jin…[et al.]. Acute Oral Toxicity and Kinetic Behaviors of Inorganic Layered Nanoparticles. Journal of Nanomaterials No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1008006
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yu, Jin& Chung, Hea-Eun& Choi, Soo-Jin. Acute Oral Toxicity and Kinetic Behaviors of Inorganic Layered Nanoparticles. Journal of Nanomaterials. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1008006
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1008006
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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