Nonalcoholic Fatty Liver Disease: Different Classifications Concordance and Relationship between Degrees of Morphological Features and Spectrum of the Disease
المؤلفون المشاركون
Monteiro, Juliana Maya
Monteiro, Geysa Maya
Caroli-Bottino, Adriana
Pannain, Vera Lucia
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-12-02
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
The morphological features of nonalcoholic fatty liver disease (NAFLD) range from steatosis to nonalcoholic steatohepatitis (NASH) and cirrhosis.
Liver biopsy remains the main tool for NASH diagnosis and many histological systems to diagnose and grade NAFLD were proposed.
We evaluated the relationship among NAFLD activity score (NAS), histological diagnoses (non-NASH, possible NASH, and definite NASH), and histological algorithm proposed by Bedossa et al.; additionally the degrees of morphological features were semiquantified and correlated with non-NASH and NASH.
Seventy-one liver biopsies were studied.
The agreement among the three systems considering NASH and non-NASH was excellent (Κ=0.96).
Among the 22 biopsies with NAS 3-4, 72.7% showed to be NASH according to Bedossa’s algorithm.
The degree of steatosis, ballooning, lobular inflammation, and fibrosis stage were correlated with NASH (P<0.001).
Fibrosis stage 1 was also found in non-NASH.
Over the spectrum of NAFLD, no association was observed between intensity of steatosis and fibrosis grade.
The degrees of lobular inflammation showed association with fibrosis stage (P<0.0001).
In conclusion, there is agreement among different NAFLD classifications and NAS > 4 may be a better cutoff from which to consider NASH diagnosis; besides the highest degrees of steatosis, ballooning, inflammation, and fibrosis are associated with NASH.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Monteiro, Juliana Maya& Monteiro, Geysa Maya& Caroli-Bottino, Adriana& Pannain, Vera Lucia. 2014. Nonalcoholic Fatty Liver Disease: Different Classifications Concordance and Relationship between Degrees of Morphological Features and Spectrum of the Disease. Analytical Cellular Pathology،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1015300
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Monteiro, Juliana Maya…[et al.]. Nonalcoholic Fatty Liver Disease: Different Classifications Concordance and Relationship between Degrees of Morphological Features and Spectrum of the Disease. Analytical Cellular Pathology No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1015300
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Monteiro, Juliana Maya& Monteiro, Geysa Maya& Caroli-Bottino, Adriana& Pannain, Vera Lucia. Nonalcoholic Fatty Liver Disease: Different Classifications Concordance and Relationship between Degrees of Morphological Features and Spectrum of the Disease. Analytical Cellular Pathology. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1015300
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1015300
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر