Beneficial Effect of Cissus quadrangularis Linn. on Osteopenia Associated with Streptozotocin-Induced Type 1 Diabetes Mellitus in Male Wistar Rats
المؤلفون المشاركون
Ranganath Pai Karkala, Sreedhara
Rao Sirasanagandla, Srinivasa
Potu, Bhagath Kumar
Bhat, Kumar M. R.
المصدر
Advances in Pharmacological and Pharmaceutical Sciences
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-04-07
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Petroleum ether fraction of Cissus quadrangularis (PECQ) impact on the development of osteopenia in type 1 diabetic rat model has been evaluated.
Diabetic rats were treated orally with two doses of PECQ.
Another group of diabetic rats were treated with subcutaneous injection of synthetic human insulin.
The cortical and trabecular bone thickness and bone strength were significantly decreased in diabetic rats.
Treatment with two doses of PECQ significantly prevented these changes in diabetic rats.
However, PECQ treatment (two doses) did not alter the glycemic levels in these diabetic rats.
Increased levels of serum alkaline phosphatase (ALP), tartrate-resistant acid phosphatase (TRAP), and hydroxyproline were noted in diabetic rats when compared to normal control rats.
The two doses of PECQ treatment further improved the serum ALP levels and significantly decreased the serum levels of TRAP and hydroxyproline.
The effects of PECQ treatment on histological, biomechanical, and biochemical parameters are comparable to those of insulin.
Since PECQ improves the bone health in hyperglycemic conditions by enhancing the cortical and trabecular bone growth and altering the circulating bone markers, it could be used as an effective therapy against diabetes-associated bone disorders.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rao Sirasanagandla, Srinivasa& Ranganath Pai Karkala, Sreedhara& Potu, Bhagath Kumar& Bhat, Kumar M. R.. 2014. Beneficial Effect of Cissus quadrangularis Linn. on Osteopenia Associated with Streptozotocin-Induced Type 1 Diabetes Mellitus in Male Wistar Rats. Advances in Pharmacological and Pharmaceutical Sciences،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1016015
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rao Sirasanagandla, Srinivasa…[et al.]. Beneficial Effect of Cissus quadrangularis Linn. on Osteopenia Associated with Streptozotocin-Induced Type 1 Diabetes Mellitus in Male Wistar Rats. Advances in Pharmacological and Pharmaceutical Sciences No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1016015
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rao Sirasanagandla, Srinivasa& Ranganath Pai Karkala, Sreedhara& Potu, Bhagath Kumar& Bhat, Kumar M. R.. Beneficial Effect of Cissus quadrangularis Linn. on Osteopenia Associated with Streptozotocin-Induced Type 1 Diabetes Mellitus in Male Wistar Rats. Advances in Pharmacological and Pharmaceutical Sciences. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1016015
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1016015
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر