Effects of Methanol Extract of Breadfruit (Artocarpus altilis) on Atherogenic Indices and Redox Status of Cellular System of Hypercholesterolemic Male Rats
المؤلفون المشاركون
Adaramoye, Oluwatosin Adekunle
Akanni, Olubukola Oyebimpe
المصدر
Advances in Pharmacological and Pharmaceutical Sciences
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-01-30
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
We investigated the effects of methanol extract of Artocarpus altilis (AA) on atherogenic indices and redox status of cellular system of rats fed with dietary cholesterol while Questran (QUE) served as standard.
Biochemical indices such as total cholesterol (TC), triglycerides (TG), low- and high-density lipoproteins-cholesterol (LDL-C and HDL-C), aspartate and alanine aminotransferases (AST and ALT), lactate dehydrogenase (LDH), reduced glutathione, glutathione-s-transferase, glutathione peroxidase (GPx), catalase (CAT), superoxide dismutase (SOD), and lipid peroxidation (LPO) were assessed.
Hypercholesterolemic (HC) rats had significantly increased relative weight of liver and heart.
Dietary cholesterol caused a significant increase ( P < 0.05 ) in the levels of serum, hepatic, and cardiac TC by 110%, 70%, and 85%, LDL-C by 79%, 82%, and 176%, and TG by 68%, 96%, and 62%, respectively.
Treatment with AA significantly reduced the relative weight of the organs and lipid parameters.
There were beneficial increases in serum and cardiac HDL-C levels in HC rats treated with AA.
In HC rats, serum LDH, ALT, and AST activities and levels of LPO were increased, whereas hepatic and cardiac SOD, CAT, and GPx were reduced.
All biochemical and histological alterations were ameliorated upon treatment with AA.
Extract of AA had protective effects against dietary cholesterol-induced hypercholesterolemia.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Adaramoye, Oluwatosin Adekunle& Akanni, Olubukola Oyebimpe. 2014. Effects of Methanol Extract of Breadfruit (Artocarpus altilis) on Atherogenic Indices and Redox Status of Cellular System of Hypercholesterolemic Male Rats. Advances in Pharmacological and Pharmaceutical Sciences،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1016017
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Adaramoye, Oluwatosin Adekunle& Akanni, Olubukola Oyebimpe. Effects of Methanol Extract of Breadfruit (Artocarpus altilis) on Atherogenic Indices and Redox Status of Cellular System of Hypercholesterolemic Male Rats. Advances in Pharmacological and Pharmaceutical Sciences No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1016017
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Adaramoye, Oluwatosin Adekunle& Akanni, Olubukola Oyebimpe. Effects of Methanol Extract of Breadfruit (Artocarpus altilis) on Atherogenic Indices and Redox Status of Cellular System of Hypercholesterolemic Male Rats. Advances in Pharmacological and Pharmaceutical Sciences. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1016017
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1016017
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر