Inhibitory Potential of Five Traditionally Used Native Antidiabetic Medicinal Plants on α-Amylase, α-Glucosidase, Glucose Entrapment, and Amylolysis Kinetics In Vitro
المؤلفون المشاركون
Picot, Carene M. N.
Mahmudi, M. Fawzi
Subratty, A. Hussein
المصدر
Advances in Pharmacological and Pharmaceutical Sciences
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-03-02
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Five traditionally used antidiabetic native medicinal plants of Mauritius, namely, Stillingia lineata (SL), Faujasiopsis flexuosa (FF), Erythroxylum laurifolium (EL), Elaeodendron orientale (EO), and Antidesma madagascariensis (AM), were studied for possible α-amylase and α-glucosidase inhibitory property, glucose entrapment, and amylolysis kinetics in vitro.
Only methanolic extracts of EL, EO, and AM (7472.92±5.99, 1745.58±31.66, and 2222.96±13.69 μg/mL, resp.) were found to significantly (P<0.05) inhibit α-amylase and were comparable to acarbose.
EL, EO, AM, and SL extracts (5000 μg/mL) were found to significantly (P<0.05) inhibit α-glucosidase (between 87.41±3.31 and 96.87±1.37% inhibition).
Enzyme kinetic studies showed an uncompetitive and mixed type of inhibition.
Extracts showed significant (P<0.05) glucose entrapment capacities (8 to 29% glucose diffusion retardation index (GDRI)), with SL being more active (29% GDRI) and showing concentration-dependent activity (29, 26, 21, 14, and 5%, resp.).
Amylolysis kinetic studies showed that methanolic extracts were more potent inhibitors of α-amylase compared to aqueous extracts and possessed glucose entrapment properties.
Our findings tend to provide justification for the hypoglycaemic action of these medicinal plants which has opened novel avenues for the development of new phytopharmaceuticals geared towards diabetes management.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Picot, Carene M. N.& Subratty, A. Hussein& Mahmudi, M. Fawzi. 2014. Inhibitory Potential of Five Traditionally Used Native Antidiabetic Medicinal Plants on α-Amylase, α-Glucosidase, Glucose Entrapment, and Amylolysis Kinetics In Vitro. Advances in Pharmacological and Pharmaceutical Sciences،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1016020
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Picot, Carene M. N.…[et al.]. Inhibitory Potential of Five Traditionally Used Native Antidiabetic Medicinal Plants on α-Amylase, α-Glucosidase, Glucose Entrapment, and Amylolysis Kinetics In Vitro. Advances in Pharmacological and Pharmaceutical Sciences No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1016020
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Picot, Carene M. N.& Subratty, A. Hussein& Mahmudi, M. Fawzi. Inhibitory Potential of Five Traditionally Used Native Antidiabetic Medicinal Plants on α-Amylase, α-Glucosidase, Glucose Entrapment, and Amylolysis Kinetics In Vitro. Advances in Pharmacological and Pharmaceutical Sciences. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1016020
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1016020
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر