Appearance of L90I and N205S Mutations in Effector Domain of NS1 Gene of pdm (09) H1N1 Virus from India during 2009–2013
المؤلفون المشاركون
Kumar, Sachin
Khare, Shashi
Saidullah, Bano
Gandhoke, Inderjeet
Ram, Hanu
Singh, Supriya
Chauhan, L. S.
Rai, Arvind
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-09-15
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
In the present study, full length sequencing of NS gene was done in 91 samples which were obtained from patients over the time period of five years from 2009 to 2013.
The sequencing of NS gene was undertaken in order to determine the changes/mutations taking place in the NS gene of A H1N1 pdm (09) since its emergence in 2009.
Analysis has shown that the majority of samples belong to New York (G1 type) strain with valine at position 123.
Effector domain of NS1 protein displays the appearance of three mutations L90I, I123V, and N205S in almost all the samples from 2010 onwards.
Phylogenetic analysis of available NS1 sequences from India has grouped all the sequences into four clusters with mean genetic distance ranging from 12% to 24% between the clusters.
Variability in length of NS1 protein was seen in sequences from these clusters, 230-amino-acid-residue NS1 for all strains from year 2007 to 2008 and for 21 strains from year 2009 and 219-residue products for 37 strains from year 2009 and all strains from year 2010 to 2013.
Mutations like K62R, K131Q, L147R, and A202P were observed for the first time in NS1 protein and their function remains to be determined.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kumar, Sachin& Khare, Shashi& Saidullah, Bano& Gandhoke, Inderjeet& Ram, Hanu& Singh, Supriya…[et al.]. 2014. Appearance of L90I and N205S Mutations in Effector Domain of NS1 Gene of pdm (09) H1N1 Virus from India during 2009–2013. Advances in Virology،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1016065
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kumar, Sachin…[et al.]. Appearance of L90I and N205S Mutations in Effector Domain of NS1 Gene of pdm (09) H1N1 Virus from India during 2009–2013. Advances in Virology No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-1016065
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kumar, Sachin& Khare, Shashi& Saidullah, Bano& Gandhoke, Inderjeet& Ram, Hanu& Singh, Supriya…[et al.]. Appearance of L90I and N205S Mutations in Effector Domain of NS1 Gene of pdm (09) H1N1 Virus from India during 2009–2013. Advances in Virology. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1016065
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1016065
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر