CpG Island Methylator Phenotype and Prognosis of Colorectal Cancer in Northeast China
المؤلفون المشاركون
Li, Xia
Hu, Fulan
Wang, Yibaina
Yao, Xiaoping
Zhang, Zuoming
Wang, Fan
Sun, Guizhi
Cui, Bin-Bin
Dong, Xinshu
Zhao, Yashuang
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-08-28
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Purpose.
To investigate the association between CpG island methylator phenotype (CIMP) and the overall survival of sporadic colorectal cancer (CRC) in Northeast China.
Methods.
282 sporadic CRC patients were recruited in this study.
We selected MLH1, MGMT, p16, APC, MINT1, MINT31, and RUNX3 as the CIMP panel markers.
The promoter methylation was assessed by methylation sensitive high resolution melting (MS-HRM).
Proportional hazards-regression models were fitted with computing hazard ratios (HR) and the corresponding 95% confidence intervals (95% CI).
Results.
12.77% (36/282) of patients were CIMP-0, 74.1% (209/282) of patients were CIMP-L, and 13.12% (37/282) of patients were CIMP-H.
The five-year survival of the 282 CRC patients was 58%.
There was significant association between APC gene promoter methylation and CRC overall survival (HR = 1.61; 95% CI: 1.05–2.46; P = 0.03 ).
CIMP-H was significantly associated with worse prognosis compared to CIMP-0 (HR = 3.06; 95% CI: 1.19–7.89; P = 0.02 ) and CIMP-L (HR = 1.97; 95% CI: 1.11–3.48; P = 0.02 ), respectively.
While comparing with the combine of CIMP-L and CIMP-0 (CIMP-L/0), CIMP-H also presented a worse prognosis (HR = 2.31; 95% CI: 1.02–5.24; P = 0.04 ).
Conclusion.
CIMP-H may be a predictor of a poor prognosis of CRC in Northeast China patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Xia& Hu, Fulan& Wang, Yibaina& Yao, Xiaoping& Zhang, Zuoming& Wang, Fan…[et al.]. 2014. CpG Island Methylator Phenotype and Prognosis of Colorectal Cancer in Northeast China. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1016160
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Xia…[et al.]. CpG Island Methylator Phenotype and Prognosis of Colorectal Cancer in Northeast China. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1016160
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Xia& Hu, Fulan& Wang, Yibaina& Yao, Xiaoping& Zhang, Zuoming& Wang, Fan…[et al.]. CpG Island Methylator Phenotype and Prognosis of Colorectal Cancer in Northeast China. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1016160
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1016160
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر