Patched Targeting Peptides for Imaging and Treatment of Hedgehog Positive Breast Tumors
المؤلفون المشاركون
Woodward, Wendy
Sims-Mourtada, Jennifer
Smith, Daniel
Kong, Fanlin
Yang, David J.
Larson, Richard
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-09-07
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
High tumor hedgehog expression is correlated with poor prognosis in invasive ductal carcinoma.
Peptides which bind the patched receptor have recently been reported to have a growth inhibitory effect in tumors with activated hedgehog signaling.
We sought to examine growth inhibition with these peptides in breast cancer cells and use these peptides as molecular imaging probes to follow changes in hedgehog expression after chemotherapy.
Significant growth inhibition was observed in breast cancer cell lines treated with PTCH-blocking peptides.
Significant in vitro uptake was observed with both FITC- and 99mTc-EC-peptide conjugates.
In vivo imaging studies displayed greater accumulation of 99mTc-labeled peptides within tumors as compared to adjacent muscle tissue.
Patched receptor expression increased after treatment and this correlated with an increase in tumor radiotracer uptake.
These studies suggest that peptides which bind the sonic hedgehog docking site in patched receptor correlate with patched expression and can be used to image patched in vivo.
Further, our data suggest that radiolabeled peptides may enable us to examine the activity of the hedgehog signaling pathway and to evaluate response to anti-cancer therapies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Smith, Daniel& Kong, Fanlin& Yang, David J.& Larson, Richard& Sims-Mourtada, Jennifer& Woodward, Wendy. 2014. Patched Targeting Peptides for Imaging and Treatment of Hedgehog Positive Breast Tumors. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1016344
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Smith, Daniel…[et al.]. Patched Targeting Peptides for Imaging and Treatment of Hedgehog Positive Breast Tumors. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1016344
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Smith, Daniel& Kong, Fanlin& Yang, David J.& Larson, Richard& Sims-Mourtada, Jennifer& Woodward, Wendy. Patched Targeting Peptides for Imaging and Treatment of Hedgehog Positive Breast Tumors. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1016344
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1016344
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر