Aptamers as Both Drugs and Drug-Carriers
المؤلف
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-21، 21ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-09-11
دولة النشر
مصر
عدد الصفحات
21
التخصصات الرئيسية
الملخص EN
Aptamers are short nucleic acid oligos.
They may serve as both drugs and drug-carriers.
Their use as diagnostic tools is also evident.
They can be generated using various experimental, theoretical, and computational techniques.
The systematic evolution of ligands by exponential enrichment which uses iterative screening of nucleic acid libraries is a popular experimental technique.
Theory inspired methodology entropy-based seed-and-grow strategy that designs aptamer templates to bind specifically to targets is another one.
Aptamers are predicted to be highly useful in producing general drugs and theranostic drugs occasionally for certain diseases like cancer, Alzheimer’s disease, and so on.
They bind to various targets like lipids, nucleic acids, proteins, small organic compounds, and even entire organisms.
Aptamers may also serve as drug-carriers or nanoparticles helping drugs to get released in specific target regions.
Due to better target specific physical binding properties aptamers cause less off-target toxicity effects.
Therefore, search for aptamer based drugs, drug-carriers, and even diagnostic tools is expanding fast.
The biophysical properties in relation to the target specific binding phenomena of aptamers, energetics behind the aptamer transport of drugs, and the consequent biological implications will be discussed.
This review will open up avenues leading to novel drug discovery and drug delivery.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ashrafuzzaman, Md.. 2014. Aptamers as Both Drugs and Drug-Carriers. BioMed Research International،Vol. 2014, no. 2014, pp.1-21.
https://search.emarefa.net/detail/BIM-1016491
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ashrafuzzaman, Md.. Aptamers as Both Drugs and Drug-Carriers. BioMed Research International No. 2014 (2014), pp.1-21.
https://search.emarefa.net/detail/BIM-1016491
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ashrafuzzaman, Md.. Aptamers as Both Drugs and Drug-Carriers. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-21.
https://search.emarefa.net/detail/BIM-1016491
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1016491
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر