A Derived Network-Based Interferon-Related Signature of Human Macrophages Responding to Mycobacterium tuberculosis
المؤلفون المشاركون
Wu, Kang
Fang, Hai
Lyu, Liang-Dong
Lowrie, Douglas B.
Wong, Ka-Wing
Fan, Xiao-Yong
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-08-31
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Network analysis of transcriptional signature typically relies on direct interaction between two highly expressed genes.
However, this approach misses indirect and biological relevant interactions through a third factor (hub).
Here we determine whether a hub-based network analysis can select an improved signature subset that correlates with a biological change in a stronger manner than the original signature.
We have previously reported an interferon-related transcriptional signature (THP1r2Mtb-induced) from Mycobacterium tuberculosis (M.
tb)-infected THP-1 human macrophage.
We selected hub-connected THP1r2Mtb-induced genes into the refined network signature TMtb-iNet and grouped the excluded genes into the excluded signature TMtb-iEx.
TMtb-iNet retained the enrichment of binding sites of interferon-related transcription factors and contained relatively more interferon-related interacting genes when compared to THP1r2Mtb-induced signature.
TMtb-iNet correlated as strongly as THP1r2Mtb-induced signature on a public transcriptional dataset of patients with pulmonary tuberculosis (PTB).
TMtb-iNet correlated more strongly in CD4+ and CD8+ T cells from PTB patients than THP1r2Mtb-induced signature and TMtb-iEx.
When TMtb-iNet was applied to data during clinical therapy of tuberculosis, it resulted in the most pronounced response and the weakest correlation.
Correlation on dataset from patients with AIDS or malaria was stronger for TMtb-iNet, indicating an involvement of TMtb-iNet in these chronic human infections.
Collectively, the significance of this work is twofold: (1) we disseminate a hub-based approach in generating a biologically meaningful and clinically useful signature; (2) using this approach we introduce a new network-based signature and demonstrate its promising applications in understanding host responses to infections.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wu, Kang& Fang, Hai& Lyu, Liang-Dong& Lowrie, Douglas B.& Wong, Ka-Wing& Fan, Xiao-Yong. 2014. A Derived Network-Based Interferon-Related Signature of Human Macrophages Responding to Mycobacterium tuberculosis. BioMed Research International،Vol. 2014, no. 2014, pp.1-16.
https://search.emarefa.net/detail/BIM-1016515
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wu, Kang…[et al.]. A Derived Network-Based Interferon-Related Signature of Human Macrophages Responding to Mycobacterium tuberculosis. BioMed Research International No. 2014 (2014), pp.1-16.
https://search.emarefa.net/detail/BIM-1016515
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wu, Kang& Fang, Hai& Lyu, Liang-Dong& Lowrie, Douglas B.& Wong, Ka-Wing& Fan, Xiao-Yong. A Derived Network-Based Interferon-Related Signature of Human Macrophages Responding to Mycobacterium tuberculosis. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-16.
https://search.emarefa.net/detail/BIM-1016515
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1016515
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر